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https://www.sciencedirect.com/science/article/pii/S0304419X11000400
Review Strategies for enhancing antibody delivery to the brain 1. Introduction. Antibodies and antibody conjugates are an important emerging class... 2. Structure and anatomic features of the blood–brain barrier. 3. Endogenous mechanisms for traversing the BBB. 4. Antibodies and the BBB. ...Author: Richard T. Frank, Karen S. Aboody, Joseph Najbauer
https://www.sciencedirect.com/science/article/abs/pii/S0304419X11000400
Multiple methods have been developed to enhance antibody delivery to the CNS, including direct injection, mechanical or biochemical disruption of the BBB, conjugation to a ‘molecular Trojan horse’, cationization, encapsulation in nanoparticles and liposomes, and more recently, stem cell-mediated antibody delivery.Author: Richard T. Frank, Karen S. Aboody, Joseph Najbauer
https://www.researchgate.net/publication/51500725_Strategies_for_enhancing_antibody_delivery_to_the_brain
Strategies for enhancing antibody delivery to the brain. Antibodies and antibody conjugates have emerged as important tools for cancer therapy. However, a major therapeutic challenge for the use of antibodies is their inability to cross the blood-brain barrier (BBB) to reach tumors localized in the central nervous system (CNS).
https://www.deepdyve.com/lp/elsevier/strategies-for-enhancing-antibody-delivery-to-the-brain-euh2X0nXRo
Dec 01, 2011 · Strategies for enhancing antibody delivery to the brain However, a major therapeutic challenge for the use of antibodies is their inability to cross the blood–brain barrier (BBB) to reach tumors localized in the central nervous system (CNS).
https://www.mdpi.com/1420-3049/23/6/1289/htm
Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Review by Isra’ Zeiadeh , Anas Najjar and Rafik Karaman * Department of Bioorganic & Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Quds University, Jerusalem P.O. Box 20002, PalestineAuthor: Isra’ Zeiadeh, Anas Najjar, Rafik Karaman
https://www.nature.com/articles/s41598-019-45577-2
Jun 25, 2019 · We next sought to compare the delivery of the different antibody formats to the brain with and without SUS in the pR5 mice. To detect the antibodies post-treatment in the pR5 mice, antibodies were labeled with Alexa-647 and the degree of labeling was calculated (Fig. 2A ).Author: Phillip W. Janowicz, Gerhard Leinenga, Jürgen Götz, Rebecca M. Nisbet
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