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https://www.researchgate.net/publication/289718261_Polymer-Based_Gene_Delivery_Systems
An ideal gene delivery system should display properties such as prolonged blood circulation, protection of the biopolymer from degradation, ability to target the specific sites of disease, correct ...
https://www.sciencedirect.com/science/article/pii/S037851739900037X
Stabilization of polymer-based gene delivery systems. ... freeze-drying and freeze-thawing were used for stabilization of these complexes. The concentration of the sugars is an important factor affecting both the size and transfection capability of the complexes after freeze-drying and freeze-thawing. ... The complexes consist of pCMV-lacZ ...Author: J.-Y Cherng, P.v.d Wetering, H Talsma, D.J.A Crommelin, W.E Hennink
https://www.ncbi.nlm.nih.gov/pubmed/10361148
Jun 10, 1999 · Stabilization of polymer-based gene delivery systems. Cherng JY(1), vd Wetering P, Talsma H, Crommelin DJ, Hennink WE. Author information: (1)Research School Groningen-Utrecht Institute for Drug Exploration (GUIDE), Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. Box 80.082, 3508 TB ...Author: J.-Y Cherng, P.v.d Wetering, H Talsma, D.J.A Crommelin, W.E Hennink
https://www.deepdyve.com/lp/elsevier/stabilization-of-polymer-based-gene-delivery-systems-ovrv06DK8C
Stabilization of polymer-based gene delivery systems Stabilization of polymer-based gene delivery systems Cherng, J.-Y; Wetering, P.v.d; Talsma, H; Crommelin, D.J.A; Hennink, W.E 1999-06-10 00:00:00 To preserve the size and transfection potential of polymer–plasmid complexes, freeze-drying and freeze-thawing were used for stabilization of these complexes.
http://europepmc.org/abstract/MED/10361148
Jun 01, 1999 · Stabilization of polymer-based gene delivery systems. J Y Cherng Research School Groningen-Utrecht Institute for Drug Exploration (GUIDE), Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, P.O. …Author: J.-Y Cherng, P.v.d Wetering, H Talsma, D.J.A Crommelin, W.E Hennink
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417261/
Mar 12, 2019 · The gene delivery systems consist of the three components such as a plasmid-based gene expression system that controls the function of a gene within the targeting cell, a gene that encodes a specific therapeutic protein, and a gene delivery system that controls the delivery of the gene expression plasmid to specific location within the body [4, 5].Author: YK Sung, SW Kim
https://link.springer.com/article/10.1023%2FA%3A1007548826495
Feb 01, 2000 · Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the ...Author: Stefaan C. De Smedt, Joseph Demeester, Wim E. Hennink
https://www.sciencedirect.com/science/article/pii/S0079670007000718
Although these safety issues do not necessarily preclude the use of viruses as gene vectors, they have motivated the exploration for safer, less pathogenic and immunogenic gene delivery alternatives including lipid-based vectors, chemically modified viruses, inorganic materials, and …Author: Sharon Y. Wong, Jeisa M. Pelet, David Putnam
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