Spinal Cord Injection Delivery

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For ALS, New Spinal Injection Method May Help Cell Therapy ...

    https://alsnewstoday.com/2020/02/10/new-spinal-delivery-method-renders-stem-cell-therapy-safer-more-effective-als-other-diseases-early-study/
    Feb 10, 2020 · “This injection technique allows the delivery of high cell numbers from a single injection,” said Marsala. “Cells with proliferative properties, such as glial progenitors, then migrate into the spinal parenchyma and populate over time in multiple spinal segments as well as the brain stem.5/5(1)

Spinal subpial delivery of AAV9 enables widespread gene ...

    https://www.nature.com/articles/s41591-019-0674-1
    Dec 23, 2019 · Injection of AAV–shRNA below the pial surface of the spinal cord prevents onset or ameliorates progression in a mouse model of ALS, and achieves widespread delivery to the spinal cord …Author: Mariana Bravo-Hernandez, Takahiro Tadokoro, Takahiro Tadokoro, Michael R. Navarro, Oleksandr Platosh...

New injection technique may boost spinal cord injury ...

    https://www.sciencedaily.com/releases/2020/01/200129125606.htm
    Jan 29, 2020 · The new technique is less invasive, depositing injected cells into the spinal subpial space -- a space between the pial membrane and the superficial layers of the spinal cord. "This injection...

An efficient intrathecal delivery ... - PubMed Central (PMC)

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1253531/
    Sep 28, 2005 · We have developed a highly effective method for in vivo gene silencing in the spinal cord and dorsal root ganglia (DRG) by a cationic lipid facilitated delivery of …Author: Miaw Chyi Luo, Dong Qin Zhang, Shou Wu Ma, Yuan Yuan Huang, Sam J. Shuster, Frank Porreca, Josephine...

Spine Injections: What You Need to Know

    https://www.spineuniverse.com/treatments/pain-management/injections/spine-injections-what-you-need-know
    A recent infection or severe allergy to a medication found in the injection may also be a disqualifying condition. Women who are pregnant sometimes choose to undergo a spinal injection after delivery to avoid being exposed to radiation. Do I need medical clearance from another doctor?

AAV gene delivery to the spinal cord: serotypes, methods ...

    https://www.tandfonline.com/doi/figure/10.1080/14712598.2018.1416089?scroll=top&needAccess=true
    (2018). AAV gene delivery to the spinal cord: serotypes, methods, candidate diseases, and clinical trials. Expert Opinion on Biological Therapy: Vol. 18, No. 3, pp ...

Injections for Back Pain: Purpose, Procedure, Side-Effects

    https://www.webmd.com/back-pain/guide/back-pain-injection-treatments
    Part of that may include injections to ease your back pain and inflammation. These shots usually consist of a steroid and a numbing medicine. Keep in mind that while these shots help some people ...

New Injection Technique May Boost Spinal Cord Injury ...

    https://health.ucsd.edu/news/releases/Pages/2020-01-29-new-injection-technique-may-boost-spinal-cord-injury-repair-efforts.aspx
    Jan 29, 2020 · The new technique is less invasive, depositing injected cells into the spinal subpial space — a space between the pial membrane and the superficial layers of the spinal cord. “This injection technique allows the delivery of high cell numbers from a single injection,” said Marsala.

Widespread and Efficient Transduction of Spinal Cord and ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426802/
    The architecture of the spinal cord makes efficient delivery of recombinant adeno-associated virus (rAAV) vectors throughout the neuraxis challenging. We describe a paradigm in which small amounts of virus delivered intraspinally to newborn mice result in robust rAAV-mediated transgene expression in the spinal cord.Author: Jacob I Ayers, Susan Fromholt, Olga Sinyavskaya, Zoe Siemienski, Awilda M Rosario, Andrew Li, Keith ...

11 Risks of Epidurals During Delivery: Itching, Fever, and ...

    https://www.healthline.com/health/pregnancy/pain-risks-epidurals
    A spinal blockalso numbs you from the waist down, but the medication is delivered via a shot into the fluid around your spinal cord. It works quickly, but the effects only last for an hour or two.Author: The Healthline Editorial Team

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