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http://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=2049&context=etd
HIGH-FREQUENCY ULTRASOUND DRUG DELIVERY AND CAVITATION Mario Alfonso D´ıaz de la Rosa Department Chemical Engineering Master of Science The viability of a drug delivery system which encapsulates chemotherapeutic drugs (Doxorubicin) in the hydrophobic core of polymeric micelles and triggers release
https://scholarsarchive.byu.edu/etd/1050/
Abstract. The viability of a drug delivery system which encapsulates chemotherapeutic drugs (Doxorubicin) in the hydrophobic core of polymeric micelles and triggers release by ultrasound application was investigated at an applied frequency of 500 kHz. The investigation also included elucidating the mechanism of drug release at 70 kHz,...Author: Mario Alfonso Diaz
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1361256/
The third major contribution of ultrasound to drug delivery relates to the stresses inflicted upon cells and tissues as a result of cavitation events. Ultrasound by itself, in the absence of cavitation, is thought to have little if any effect on cells and tissues apart from some heating that may occur at higher frequencies and intensities [ 6 , 23 , 30 , 31 ].Author: William G. Pitt, Ghaleb A. Husseini, Bryant J. Staples
https://www.guidedtherapy.com/wp-content/uploads/2015/04/Feasibility-of-Ultrasound-Assisted-Drug-Delivery.pdf
Abstract—Use of low frequency, low intensity ultrasound for transdermal drug delivery associated with cavitation is known [1]. We propose to establish feasibility of ultrasound assisted drug delivery using high frequency (2-10 MHz) intense therapy ultrasound with intensities up to 12 kW/cm² and acoustic pressure up to 30 MPa.
https://www.nature.com/articles/s42254-019-0074-y
Jun 17, 2019 · Ultrasound-responsive microparticles and nanoparticles can either be used as drug carriers or co-administered with a free drug into the bloodstream, providing cavitation …Author: Eleanor Stride, Constantin Coussios
https://www.sciencedirect.com/science/article/pii/S0301562920300041
This review summarizes recent investigations that have elucidated interactions of ultrasound and cavitation nuclei with cells, the treatment of tumors, immunotherapy, the blood–brain and blood–spinal cord barriers, sonothrombolysis, cardiovascular drug delivery and sonobactericide.Author: Klazina Kooiman, Silke Roovers, Simone A.G. Langeveld, Robert T. Kleven, Heleen Dewitte, Heleen Dewi...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436072/
Jun 30, 2011 · The use of ultrasound for the delivery of drugs to, or through, the skin is commonly known as sonophoresis or phonophoresis. The use of therapeutic and high frequencies of ultrasound (≥ 0.7 MHz) for sonophoresis (HFS) dates back to as early as the 1950s, while low-frequency sonophoresis (LFS, 20 – 100 kHz) has only been investigated significantly during the past two decades.Author: Baris E. Polat, Douglas Hart, Robert Langer, Daniel Blankschtein
https://www.ndorms.ox.ac.uk/publications/1097016
Therapeutic ultrasound strategies that harness the mechanical activity of cavitation nuclei for beneficial tissue bio-effects are actively under development. The mechanical oscill
https://www.sciencedirect.com/science/article/pii/S0927776520300795
For ultrasound-sensitive nanodroplets designed for drug delivery, in vivo contrast-enhanced imaging performance relying on the phase transition plays an important role in diagnosis and targeted drug …Author: Yaqiong Li, Ruiqing Liu, Luwen Liu, Ye Zhang, Jun Sun, Peizhi Ma, Yuejin Wu, Shaobo Duan, Lianzhong ...
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