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https://www.sciencedirect.com/science/article/pii/S0378517308000215
May 22, 2008 · Pharmaceutical Nanotechnology Solid lipid nanoparticles for pulmonary delivery of insulin 1. Introduction. Recently, pulmonary route, as an alternative non-invasive approach... 2. Materials and methods. Pure crystalline porcine insulin …Author: Jie Liu, Tao Gong, Hualin Fu, Changguang Wang, Xiuli Wang, Qian Chen, Qin Zhang, Qin He, Zhirong Zha...
https://www.researchgate.net/publication/5571325_Solid_lipid_nanoparticles_for_pulmonary_delivery_of_insulin
In this study, novel nebulizer-compatible solid lipid nanoparticles (SLNs) for pulmonary drug delivery of insulin were developed by reverse micelle-double emulsion method. The influences of the...
https://www.ncbi.nlm.nih.gov/pubmed/20055110
However, sustained release formulations for pulmonary delivery have not been fully exploited till now. In our study, a novel dry powder inhalation (DPI) system of insulin loaded solid lipid nanoparticles (Ins-SLNs) was investigated for prolonged drug release, improved stability and effective inhalation.Author: Ru Bi, Wei Shao, Qun Wang, Na Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619439/
Oct 24, 2015 · Solid lipid insulin nanoparticles. As an alternative to polymeric nanoparticles, solid lipid nanoparticles (SLN) were developed for drug delivery nanoparticulate system . SLN is sub micron, around 50–1000 nm in diameter, colloidal carriers made up of lipids which are solid at room temperature.Author: Garima Sharma, Garima Sharma, Ashish Ranjan Sharma, Ju-Suk Nam, George Priya C. Doss, Sang-Soo Lee, ...
https://www.sciencedirect.com/topics/chemistry/solid-lipid-nanoparticle
Insulin solid lipid nanoparticles for pulmonary drug delivery were developed by a reverse micelle-double emulsion method with stearic and palmitic acids, soybean phosphatidylcholine, and Poloxamer 188. Optimal results of entrapment delivery (96.53%), respirable fraction (82.11%), and nebulization efficiency (63.28%) were achieved.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676823/
Preparation of solid lipid nanoparticles. The method chosen for the preparation of nanoparticles was an adaptation of the w/o/w double emulsion technique (Garcia-Fuentes et al 2003; Zhang et al 2006). 200 mg of cetyl palmitate was dissolved in 4 mL of dichloromethane. 7 mg of insulin was dissolved in 0.5 mL of HCL 0.1 M.The insulin solution was added to the lipid solution and then homogenized ...Author: Bruno Sarmento, Susana Martins, Domingos Ferreira, Eliana B Souto
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383223/
Insulin is the drug therapy for patients with insulin-dependent diabetes mellitus (or type 1 diabetes), 1 and it is an important hormone for the regulation of blood glucose level. Its aggregation and consequent precipitation has been a major barrier to the development of long-term delivery.Author: Sampath Malathi, Perumal Nandhakumar, Velayudham Pandiyan, Thomas J Webster, Sengottuvelan Balasubra...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578209/
Preparation of budesonide-loaded solid lipid nanoparticles . Budesonide-loaded SLNs were prepared by the emulsification-solvent diffusion method. Briefly, fixed amount of budesonide (2 mg) and different quantities of lipid materials were dissolved in 2 ml acetone/ethanol mixture at various proportions (Table 1). The aqueous phase contained different percentages of PVA or PLX in different volumes.
https://www.sciencedirect.com/science/article/pii/S0168365917308283
Nanoparticles have demonstrated significant advancements in potential oral delivery of insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid nanoparticles designed for oral administration of insulin.Author: Chun Y. Wong, Hani Al-Salami, Crispin R. Dass
https://in.linkedin.com/in/dr-raviraj-ravi-pillai-287a86a4
* Assessed pharmacological activity of aerosolized insulin delivered to the lung for reducing blood glucose level in fasting Rhesus monkeys. ... characterization and in-vivo evaluation of Raloxifiene solid-lipid nanoparticles Pharmaceutical ... Sonic Nebulized Nucleic Acid/Cationic Liposome Complexes and Methods for Pulmonary Gene Delivery ...Title: Sr. Director and Head, …
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