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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429665/
Jul 04, 2012 · Due to its extreme lipophilicity, the oral delivery of cinnarizine (CN) encounters several problems such as poor aqueous solubility and pH-dependent dissolution, which result in low and erratic bioavailability. The current study aims to design self-nanoemulsifying drug delivery systems (SNEDDS) of CN that circumvent such obstacles.Author: Ahmad Abdul-Wahhab Shahba, Kazi Mohsin, Fars Kaed Alanazi
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572212/
May 24, 2019 · In this study, SNEDDS based on small chain triglycerides (SCT), medium chain triglycerides (MCT), and long-chain triglycerides (LCT) for oral delivery of highly lipophilic drug chlorpromazine, were successfully designed with the significantly superior features based on different component ratios.Author: Jeand Baloch, Muhammad Farhan Sohail, Hafiz Shaib Sarwar, Maria Hassan Kiani, Gul Majid Khan, Sarwat...
https://www.sciencedirect.com/science/article/pii/B9780128136874000128
Formulation of lipid-based nanocarriers, such as self-nanoemulsifying drug delivery systems (SNEDDS) and self-microemulsifying drug delivery systems (SMEDDS) have received a lot of attention in recent years as an approach for overcoming poor solubility and oral bioavailability of drugs.Author: Marko Krstić, Đorđe Medarević, Jelena Đuriš, Svetlana Ibrić
https://www.sciencedirect.com/science/article/pii/S0378517309006048
Jan 04, 2010 · The aim of the present study was to develop a self-nanoemulsifying drug delivery system (SNEDDS) for the oral delivery of Zedoary turmeric oil (ZTO), an essential oil extracted from the dry rhizome of Curcuma zedoaria.Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification regions.Author: Yi Zhao, Changguang Wang, Albert H.L. Chow, Ke Ren, Tao Gong, Zhirong Zhang, Ying Zheng
https://www.medscape.com/viewarticle/734501_6
Nov 01, 2019 · Self-nanoemulsifying drug delivery systems (SNEDDS) are nanoemulsion preconcentrates or anhydrous forms of nanoemulsion. These systems are anhydrous isotropic mixtures of oil, surfactant(s) and ...
https://www.hindawi.com/journals/bmri/2018/6763057/
The main purpose of this study was to investigate the potential of self-nanoemulsified drug delivery system (SNEDDS) to improve the oral bioavailability of tetrandrine (Tet). SNEDDS was developed by using rational blends of excipients with good solubilizing ability for Tet which was selected based on solubility studies. Further ternary phase diagram was constructed to determine the self ...Author: Chunxia Liu, Li Lv, Wei Guo, Lan Mo, Yaoxing Huang, Guocheng Li, Xingzhen Huang
https://www.pharmaexcipients.com/news/insulin-in-a-self-nanoemulsifying-drug-delivery-system/
In an in vivo study, Wistar rats with induced diabetes showed a 36.1% reduction in blood glucose levels after 4 h of administering the modified phospholipid SNEDDS, and a 1.8% bioavailability with respect to the subcutaneous application of insulin. See the article on self-nanoemulsifying drug delivery systemAuthor: Markus Köbel
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