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https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/drug-delivery-of-small-molecule
An optimal drug buildup in the skin, with little or no flux through the skin, is desirable, which does not occur in transdermal delivery. The topical delivery of small molecule drugs has been used to deliver therapeutics transdermally and transmucosally.
https://www.cell.com/trends/molecular-medicine/pdf/S1471-4914(10)00113-9.pdf
biodistribution of the drug-carrying nanoparticles limits toxicity in major organs. Here, we discuss existing nano-particles for the delivery of small-molecule anticancer agents and recent advances in this field. Advantages of nanoparticles for the delivery of small-molecule anticancer agents In recent years, the development of therapeutic ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064947/
Jun 16, 2014 · Pathways for Small Molecule Delivery to the Central Nervous System Across the Blood-Brain Barrier John L Mikitsh 1 and Ann-Marie Chacko 1, 2 1 Department of Radiology, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.Author: John L. Mikitsh, Ann-Marie Chacko
https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201915521
examples of small-molecule activation for controlling cellular process and drug delivery. These GEAs are enzymes that activate precursors without covalent binding (Figure 1B). We providean overviewofvarioustypesofGEAs, comparethem based on either their fluorogenicity (increase in fluorescence upon binding) or kinetics of probe activation, and ...Author: Zacharias Thiel, Jade Nguyen, Pablo Rivera-Fuentes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729441/
Using nanoparticles for the delivery of small molecules in anticancer therapy is a rapidly growing area of research. The advantages of using nanoparticles for drug delivery include enhanced water solubility, tumor-specific accumulation and improved antitumor efficacy, while reducing nonspecific toxicity.Author: Zhuo (Georgia) Chen
https://pubs.acs.org/doi/10.1021/acsami.8b22516
Light-cross-linked small-molecule micelles with enediyne units are designed for developing efficient drug-delivery systems. Gemcitabine (GEM) is chosen as a model hydrophilic drug and tethered with a maleimide-based enediyne (EDY) as a hydrophobic tail in the preparation of amphiphilic EDY–GEM.Author: Baojun Li, Yuequn Wu, Yue Wang, Mengsi Zhang, Huimin Chen, Jing Li, Runhui Liu, Yun Ding, Aiguo Hu
https://www.sciencedirect.com/science/article/pii/S1818087619306816
Evolution from small molecule to nano-drug delivery systems - An emerging approach for cancer therapy of ursolic acid. Author links open overlay panel Jingwei Shao a b # Yifan Fang a # Ruirui Zhao a Fangmin Chen a Mingyue Yang a Jiali Jiang a Zixuan Chen a Xiaotian Yuan a Lee Jia a b. Show more.
https://pubs.acs.org/doi/abs/10.1021/ja505212y
All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug delivery system for cancer therapy is imperative. Here, we develop a drug self-delivery system for cancer therapy, in which anticancer drugs can be delivered by themselves without any carriers.Author: Ping Huang, Dali Wang, Yue Su, Wei Huang, Yongfeng Zhou, Daxiang Cui, Xinyuan Zhu, Deyue Yan
https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201303222
As a small‐molecule drug intercalating the nuclear DNA, Dox is loaded in the aqueous core of the liposome, while TRAIL, acting on the death receptor (DR) on the plasma membrane, is encapsulated in the outer shell made of crosslinked hyaluronic acid (HA).Author: Tianyue Jiang, Tianyue Jiang, Ran Mo, Ran Mo, Adriano Bellotti, Jianping Zhou, Zhen Gu
https://en.wikipedia.org/wiki/Small_molecule_drug_conjugate
Small molecule drug conjugates or SMDCs are built with three modules: a targeting ligand, a linker and a drug payload.The targeting ligands consist of low molecular weight, high-affinity ligands that are precisely linked to potent drugs.
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