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https://keranetics.com/small-molecule-delivery/
Keratin Hydrogel as a Small Molecule Delivery Vehicle Local, tissue-specific small molecule delivery is a growing need for many therapeutic and regenerative medicine strategies. Unfortunately, the majority of current biomaterial delivery vehicles are unable to provide desirable release kinetics, formulation options, degradation profiles, and/or biocompatibility characteristics necessary for ...
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/drug-delivery-of-small-molecule
The topical delivery of small molecule drugs has been used to deliver therapeutics transdermally and transmucosally. Again, because of the size of the protein, it is often not feasible to deliver enough protein to achieve systemic levels of the drug.
https://pubs.acs.org/doi/abs/10.1021/ja505212y
All drugs for cancer therapy face several transportation barriers on their tortuous journey to the action sites. To overcome these barriers, an effective drug delivery system for cancer therapy is imperative. Here, we develop a drug self-delivery system for cancer therapy, in which anticancer drugs can be delivered by themselves without any carriers.Author: Ping Huang, Dali Wang, Yue Su, Wei Huang, Yongfeng Zhou, Daxiang Cui, Xinyuan Zhu, Deyue Yan
https://www.ncbi.nlm.nih.gov/pubmed/30580240
Feb 01, 2019 · Three ADC products (trastuzumab emtansine, brentuximab vedotin and inotuzumab ozogamicin) are already on the market, and several compounds are in clinical trials. Compared with ADCs, small molecule-drug conjugates (SMDCs) provide a new, less established perspective for …Author: Chunlin Zhuang, Xianghong Guan, Hao Ma, Hui Cong, Wannian Zhang, Zhenyuan Miao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729441/
Owing to its small size and stability, affibodies have great potential as ligands on TNPs for targeting the delivery of small-molecule anticancer agents. Once active targeting is achieved, the next important question is whether the targeted TNPs can be internalized by the target cell.Author: Zhuo (Georgia) Chen
https://www.catalent.com/specialty/small-molecule-injectable/
» Small Molecule Injectable. Injectable Delivery. Catalent Locations Videos. OVERVIEW. Catalent’s drug product manufacturing can formulate, fill and package your product into a final vial, syringe or cartridge presentation, making it ready to use for the patient or health care professional.
https://www.cell.com/trends/molecular-medicine/pdf/S1471-4914(10)00113-9.pdf
Small-molecule delivery by nanoparticles for anticancer therapy Zhuo (Georgia) Chen Department of Hematology and Medical Oncology, Emory University School of …
http://www.umass.edu/cbd/research-themes/small-molecule-delivery-nutraceuticals
Understand the self-assembly of carrier molecules and utilize them to develop efficient delivery vehicles for small molecules and nutraceuticals. These molecules are non-covalently encapsulated in carriers or developed in a pro-drug format. Strategies for controlled release and targeted delivery to specific cells and tissues are being developed.
http://pubs.acs.org/doi/abs/10.1021/jacs.6b07204
Carbonic anhydrase converts COS into H2S, allowing NTAs to serve as either COS or H2S donors, depending on the availability of the enzyme. Analysis of the pseudo-first-order H2S release rate under biologically relevant conditions revealed a release half-life of …Author: Chadwick R. Powell, Jeffrey C. Foster, Benjamin Okyere, Michelle H. Theus, John B. Matson
https://pubs.rsc.org/en/content/articlelanding/2019/bm/c9bm00907h
As a significant part of molecular-targeted therapies, small-molecule agents (SMAs) have been increasingly used for cancer treatment. Nevertheless, most SMAs are currently administered orally due to their poor solubility, resulting in a low bioavailability and unavoidable side effects. Herein, we proposed aAuthor: Liying Wang, Xinru You, Qi Lou, Siyu He, Junfu Zhang, Chunlei Dai, Meng Zhao, Minyi Zhao, Hai Hu, Ju...
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