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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
https://www.nature.com/articles/nature05901
Jun 17, 2007 · Attachment of a piece of viral protein to a small RNA achieves transfer of the RNA into neuronal cells in cell culture. This was also able to deliver an antiviral siRNA specifically into the ...Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.sciencedirect.com/topics/neuroscience/small-interfering-rna
Small interfering RNA (siRNA) mediated inhibition of gene expression has rapidly become a major tool for in vitro analysis of protein function. In vivo gene silencing by siRNAs will play an important role for target validation and is the first step towards the development of siRNA-based therapeutics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728206/
Gold, Poly(β-amino ester) Nanoparticles for Small Interfering RNA Delivery Jae-Seung Lee , † Jordan J. Green , ‡ Kevin T. Love , § Joel Sunshine , ‡ Robert Langer , § and Daniel G. Anderson * §Author: Jae-Seung Lee, Jordan J. Green, Kevin T. Love, Joel Sunshine, Robert Langer, Daniel G. Anderson
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/small-interfering-rna
Small interfering RNA (siRNA), with length in 20–25 bp, is a short double-stranded RNA molecule. siRNA has been recognized as a promising therapeutic for antiviral, anticancer, or other genetic diseases (Li & Huang, 2006; Xue, Liu, & Wong, 2014; Zhao, Mi, & Feng, 2013). Currently, biomedical application of siRNA is still limited due to the ...
https://advances.sciencemag.org/content/5/9/eaaw6499.full
Sep 01, 2019 · RNA interference (RNAi) technology can specifically silence the expression of a target gene and has emerged as a promising therapeutic method to treat cancer. In the present study, we showed that natural halloysite nanotube (HNT)–assisted delivery of an active small interfering RNA (siRNA) targeting receptor-interacting protein kinase 4 ( RIPK4 ) efficiently silenced its expression to …Author: Jianye Liu, Yi Zhang, Qinghai Zeng, Hongliang Zeng, Xiaoming Liu, Pei Wu, Hongyi Xie, Leye He, Zhi L...
https://link.springer.com/article/10.1007%2Fs12274-017-1946-z
Aug 02, 2018 · We report the development of a small interfering RNA (siRNA) delivery vector based on cationic perfluorocarbon nanoemulsions. ... Development of fluorinated polyplex nanoemulsions for improved small interfering RNA delivery and cancer therapy ... K., Wu, P. et al. Development of fluorinated polyplex nanoemulsions for improved small interfering ...Author: Gang Chen, Kaikai Wang, Pengkai Wu, Yixin Wang, Zhanwei Zhou, Lifang Yin, Minjie Sun, David Oupický,...
http://www.nature.com/articles/nbt1101
May 22, 2005 · Delivery of small interfering RNAs (siRNAs) into cells is a key obstacle to their therapeutic application. We designed a protamine-antibody fusion protein to deliver siRNA to HIV-infected or ...Author: Erwei Song, Pengcheng Zhu, Sang Kyung Lee, Dipanjan Chowdhury, Steven Kussman, Derek M Dykxhoorn, Yi...
http://www.thno.org/v04p1211.htm
Functional Nanostructures for Effective Delivery of Small Interfering RNA Therapeutics . Cheol Am Hong 1, Yoon Sung Nam 1,2,3 . 1. Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 305-701, Republic of Korea; 2.
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