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http://science.sciencemag.org/content/254/5037/1509
Dec 06, 1991 · A recombinant gene encoding human growth hormone (hGH) was stably introduced into cultured myoblasts with a retroviral vector. After injection of genetically engineered myoblasts into mouse muscle, hGH could be detected in serum for 3 months.
https://web.stanford.edu/group/blau/pdfs/Dhawan-1991-Systemic%20delivery%20of.pdf
myoblasts are not altered by high levels ofhGHexpression as shown byNorthern (RNA) analysis of total RNAisolated from a pool ofgenetically engineered proliferating myoblasts at lowdensity (MB) and3 days later fromreplicate cultures ofpostmitotic multinucleated myotubes (MT).
https://science.sciencemag.org/content/254/5037/1507
Dec 06, 1991 · Thus, genetically engineered myoblasts can be used for the stable delivery of recombinant proteins into the circulation. The ability to stably deliver recombinant proteins to the systemic circulation would facilitate the treatment of a variety of acquired and inherited diseases.Author: Eliav Barr, Jeffrey M. Leiden
https://www.jstor.org/stable/2879441
feasibility of the use of genetically engineered myoblasts as a recombinant protein delivery system, stable transfectants of the murine C2C12 myoblast cell line were produced that synthesize and secrete high levels of human growth hormone (hGH) in vitro. Mice injected with hGH-transfected myoblasts had significant levels of hGH in both muscle and serum that were stable for at least 3 weeks after injection…
http://europepmc.org/articles/PMC45147/
Nov 01, 1994 · Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Dhawan J, Pan LC, Pavlath GK, Travis MA, Lanctot AM, Blau HM. Science, 254(5037):1509-1512, 01 Dec 1991 Cited by: 170 articles PMID: 1962213
https://www.researchgate.net/publication/14273412_Tissue-Engineered_Skeletal_Muscle_Organoids_for_Reversible_Gene_Therapy
Genetically modified murine skeletal myoblasts were tissue engineered in vitro into organ-like structures (organoids) containing only postmitotic myofibers secreting pharmacological levels of recombinant human growth hormone (rhGH).
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46544/
May 15, 1993 · Somatic gene therapy is an interesting approach for the delivery of cytokines for prolonged periods. The present experiments show that direct injections into mouse skeletal muscle of cDNA expression vectors encoding interleukin 2 (IL-2), IL-4, or type beta 1 transforming growth factor (TGF-beta 1) induce biological effects characteristic of these cytokines in vivo.Author: Eyal Raz, A. Watanabe, S. M. Baird, R. A. Eisenberg, T. B. Parr, M. Lotz, T. J. Kipps, D. A. Carson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290930/
Jun 02, 1994 · Primary myoblasts were dependent on added bFGF for growth and retained the ability to differentiate even after 30 population doublings. The fate of the pure myoblast populations after transplantation was monitored by labeling the cells with the marker enzyme beta-galactosidase (beta-gal) using retroviral mediated gene transfer.
https://www.liebertpub.com/doi/abs/10.1089/hum.1997.8.16-1867
These cells were genetically engineered in culture by adenoviral transduction to secrete human growth hormone (hGH). When injected intraperitoneally as a cell suspension into athymic mice, they yielded high plasma levels of hGH for several weeks. These results demonstrate an effective system for ex vivo gene therapy using mesothelial cells.Author: Jo-Ellen Murphy, James G. Rheinwald
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45270/
Nov 22, 1994 · Systemic delivery of human growth hormone by injection of genetically engineered myoblasts. Science. 1991 Dec 6; 254 (5037):1509–1512. Roman M, Axelrod JH, Dai Y, Naviaux RK, Friedmann T, Verma IM. Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine ...Author: Sandeep K. Tripathy, Eugene Goldwasser, Min-Min Lu, Eliav Barr, Jeffrey M. Leiden
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