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https://www.sciencedirect.com/science/article/pii/S0169409X07000439
Solid lipid nanoparticles as a drug delivery system for peptides and proteins ... mucosal absorption has been rather neglected in the advanced drug delivery market, ... S. GohlaSolid lipid nanoparticles (SLN) for controlled drug delivery — a review of the state of the art. Eur. J. Pharm. Biopharm., 50 (2000), pp. 161-177. Google Scholar.Author: António J. Almeida, Eliana Souto
https://en.wikipedia.org/wiki/Solid_lipid_nanoparticle
Carvedilol-loaded solid lipid nanoparticles were prepared using hot-homogenization technique for oral delivery using compritol and poloxamer 188 as a lipid and surfactant, respectively. Another example of drug delivery using SLN would be oral solid SLN suspended in distilled water, which was synthesized to trap drugs within the SLN structure.
https://www.sciencedirect.com/science/article/pii/S0939641197001501
The melting points of the drug-loaded SLN were below the lipid, but similar to the drug-free SLN. The melting point of the lipid was close to the theoretical value of 46.4°C for the β modification , the β′ being 12.5°C lower . Apart from the SLN loaded with 10% drug, the melting enthalpies were similar to drug-free particles . The ...Author: Annette zur Mühlen, Cora Schwarz, Wolfgang Mehnert
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865805/
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine and research, as well as in other varied sciences. Due to their unique size-dependent ...
https://www.ncbi.nlm.nih.gov/pubmed/10840199
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Müller RH(1), Mäder K, Gohla S. Author information: (1)Department of Pharmaceutical Technology, Biopharmaceutics and Biotechnology, Free University of Berlin, D-12169, Berlin, Germany.Author: Rainer H. Müller, Karsten Mäder, Sven Gohla
https://www.hindawi.com/journals/jdd/2012/750891/
Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients. These have been exploited for many features in the field of pharmaceutical technology. Lipids usually enhance drug absorption in the gastrointestinal tract (GIT), and when formulated as nanoparticles, these molecules improve mucosal adhesion due to small particle size …Author: Patrícia Severino, Tatiana Andreani, Ana Sofia Macedo, Joana F. Fangueiro, Maria Helena A. Santana, ...
http://www.icpjonline.com/documents/Vol1Issue11/08.pdf
Solid lipid nanoparticles (SLN) have emerged as a next-generation drug delivery system with potential applications in pharmaceutical field, cosmetics, research, clinical medicine and other allied sciences. Recently, increasing attention has been focused on these SLN as colloidal drug carriers for incorporating hydrophilic or lipophilic drugs.
https://drug-dev.com/lipid-based-delivery-advanced-lipid-based-drug-delivery-systems-solid-lipid-nanoparticles-nanostructured-lipid-carriers/
The use of lipid-based drug delivery systems in pharmaceutical product development is increasing due to the versatility of functional lipid excipients and the compatibility of these excipients with liquid, semi-solid, and solid pharmaceutical dosage forms. 1 In addition to solubility and bioavailability enhancement, functional lipids have been ...
https://www.researchgate.net/publication/284406370_SLN_BRAIN_TARGETING_DRUG_DELIVERY_FOR_CNS_A_NOVEL_APPROACH
SLN BRAIN TARGETING DRUG DELIVERY FOR CNS: A NOVEL APPROACH. ... uses and highlighting of various approaches and merits of SLN for brain targeting drug delivery as colloidal drug carriers.
https://www.tandfonline.com/doi/abs/10.1080/17425247.2020.1727883
Article highlights. Lipid nanoparticles possess important application for topical, dermal, and transdermal drug delivery. Both SLN and NLC can be prepared by different techniques, with the advantage of being an easy scale up production.Author: Eliana B. Souto, Eliana B. Souto, Iara Baldim, Iara Baldim, Wanderley P. Oliveira, Rekha Rao, Nitesh...
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