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https://www.brainkart.com/article/Delivery-of-Proteins--Site-Specific-Delivery--Targeting--of-Protein-Drugs_14311/
Dec 06, 2017 · SITE-SPECIFIC DELIVERY (TARGETING) OF PROTEIN DRUGS (1) The active compound never reaches the target site, because it is rapidly eliminated intact from the body through the kidneys, or it is inactivated through metabolic action (e.g., in the liver). (3) Only a small fraction of the drug reaches the target site.
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(98)01186-X.pdf
define site-specific drug delivery as delivery through a specific site (i.e. the route of administration) as well as delivery to a specific site (i.e. the site of action). Vari-ous routes of administration have been investigated to deliver proteins and peptides, including pulmonary, oral, mucosal-membrane and transcutaneous1–12.
https://onlinelibrary.wiley.com/doi/10.1002/smll.201970218
Oct 01, 2019 · In article number 1902998, Ran Mo and co‐workers develop a liposome‐based assembly for site‐specific delivery of an apoptotic protein and a tumor‐suppressor gene. The liposome can deliver cargoes to their differential intracellular targets as represented by the melting snow from the mountains feeding two rivers, therefore enhancing the combined anticancer effect as represented by the rivers …Author: Xiaojie Chen, Qiuwen Zhu, Xiao Xu, Shiyang Shen, Ying Zhang, Ran Mo
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956587/
The protein must still reach its target site, and as many of the targets for protein drugs are intraceullular, this means transport through the circulation to the appropriate site, uptake by the appropriate cells and activity of the protein inside these cells.Author: Benjamin J Bruno, Geoffrey D Miller, Carol S Lim
https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201902998
Sequentially Site‐Specific Delivery of Apoptotic Protein and Tumor‐Suppressor Gene for Combination Cancer Therapy Xiaojie Chen State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009 ChinaAuthor: Xiaojie Chen, Qiuwen Zhu, Xiao Xu, Shiyang Shen, Ying Zhang, Ran Mo
https://www.sciencedirect.com/science/article/pii/B978012816200200013X
Drug delivery systems and their development as targeted or site-specific delivery systems have fascinated the formulation scientists as a tool to overcome the drawbacks related to drugs and increase safety and efficacy with better patient compliance.Author: Tripti Shukla, Neeraj Upmanyu, Sharad P. Pandey, M.S. Sudheesh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857543/
Lipid drug delivery is another area that has shown great promise for use with therapeutic proteins. 116 – 118 As a whole, lipid delivery encompasses liposomes, solid lipid nanoparticles, oily suspensions, submicron lipid emulsions, lipid implants, lipid microbubbles, inverse lipid micelles, cochliar liposomes, and lipid microtubules, and lipid microcylinders (Figure 3A). 119 The most …Author: Dipak S. Pisal, Matthew P. Kosloski, Sathy V. Balu-Iyer
https://www.researchgate.net/publication/228779338_Targeted_drug_delivery_Site_specific_drug_delivery
The conventional drugs used so far are small organic molecules meant to degrade the diseased protein, formed as a result of the interference of pathogens at cellular level. A high concentration of these drugs in the cells is necessary for desired therapeutic effect. This aggravates the problem of toxicity.
https://link.springer.com/chapter/10.1007%2F978-3-642-59990-3_3
Drug targeting and delivery, Harwood Academic Publishers, Gmbh, Amsterdam, The Netherlands Google Scholar Laube BL, Georgopoulos A, Adams GK (1993) Preliminary study of the efficacy of aerosolized insulin delivered by oral inhalation in diabetic patients.Author: C. R. Middaugh, R. Pearlman
https://www.sciencedirect.com/science/article/pii/S016836590600201X
In order to achieve the successful oral delivery of protein drugs, they need to be protected from the harsh environment in the stomach. For designing oral dosage forms, the formulator must consider that the natural pH environment of GI tract varies from acidic (pH ∼ 1.2) in the stomach to slightly alkaline in the intestine (pH ∼ 7.4) .Author: Meera George, T. Emilia Abraham
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