We have collected information about Sirna Lung Delivery for you. Follow the links to find out details on Sirna Lung Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160355/
Aug 30, 2014 · Local delivery of siRNA into the lung, however, allows for noninvasive access and avoids interactions with serum proteins that degrade siRNA after i.v. administration. However, serum is absent on the air-side of the lung, and nuclease activity is comparably low [ 10 ].Author: Olivia M. Merkel, Israel Rubinstein, Thomas Kissel
https://www.sciencedirect.com/science/article/pii/S0169409X14001306
Local delivery of siRNA into the lung, however, allows for noninvasive access and avoids interactions with serum proteins that degrade siRNA after i.v. administration. However, serum is absent on the air-side of the lung, and nuclease activity is comparably low [10] .Author: Olivia M. Merkel, Israel Rubinstein, Thomas Kissel
https://www.future-science.com/doi/full/10.4155/tde-2019-0009
Apr 17, 2019 · The primary barrier for pulmonary siRNA delivery is the extensively branched structure of the airways with variable lengths and diameters, followed by the presence of lung fluids, such as mucus and surfactant , as well as mucociliary clearance mechanisms including alveolar macrophages.Author: Rima Kandil, Olivia M Merkel
https://www.sciencedirect.com/science/article/pii/S0169409X11000408
The term ‘naked siRNA’ or ‘unformulated siRNA’ refers to the delivery of siRNA without using any delivery agent. This includes the delivery of both unmodified siRNA and modified siRNA, formulated in saline or other simple excipients such as 5% dextrose.Author: Jenny Ka-Wing Lam, Wanling Liang, Hak-Kim Chan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621305/
Importantly, the facility of topical delivery via either intranasal, intratracheal or aerosol administration suggests the lung as an ideal target organ for siRNA-based therapeutics. Indeed, studies have shown siRNA-mediated attenuation of cytokine ( 7 ) and heme oxygenase-1 ( 8 ) induced expression during acute lung injury.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255578/
Delivery of siRNA exclusively to the endothelial cells of the lung may indicate direct transfer of the nanocomplexes from circulation to the cells lining the capillary bed. Although a greater mass amount of siRNA is recovered from the liver tissue, the siRNA content per unit tissue mass is nearly equivalent across these two organs shortly after administration.Author: Kevin J Polach, Majed Matar, Jennifer Rice, Gregory Slobodkin, Jeff Sparks, Richard Congo, Angela Re...
Searching for Sirna Lung Delivery?
You can just click the links above. The data is collected for you.
