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http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://umassmed.edu/khvorovalab/
Khvorova Lab. Coffee with Anastasia. Read more >> ... We believe that modulation of RNA chemistry is the way to enable delivery to wide range of tissues. A recent breakthrough in conjugate-mediated delivery of siRNA was the development by Alnylam Pharmaceuticals of siRNA conjugated to GalNAc (triple n-acetylgalactosamine), which drives ...
The Oupicky Lab focuses on exploring polymers and nanoparticles for delivery of drugs and nucleic acids. We are especially interested in pharmacologically active polymers (polymeric drugs) and in delivery vectors suitable for delivery of drug/gene, …
https://oupickylab.org/research/
The Oupicky Lab focuses on the broad field of drug delivery and nanomedicine, with emphasis on delivery of therapeutic nucleic acids and drug/nucleic acid combinations. Our research promises to enable or significantly improve a range of therapeutic approaches investigated in the …
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/getting-started-with-rnai-in-vivo.html
Technology exploiting this phenomenon may be used for functional genomics and target validation, and is being developed for therapeutic purposes. Because of its potency, siRNA has rapidly become the most widely used trigger for inducing gene knockdown in cultured mammalian cells. siRNA delivery in vivo is a more challenging task.
https://www.sciencedirect.com/science/article/pii/S016836592030122X
Nowadays, a commercially available lipid polymers was also used for in vivo siRNA delivery in the peripheral nervous system to treat the Charcot-Marie-Tooth (CMT) disease . CMT is the most common hereditary neurogenic disorders with a prevalence of 1:2500 worldwide.Author: Marie Caillaud, Mévidette El Madani, Liliane Massaad-Massade
https://hammondlab.mit.edu/research/
Recently, the Hammond lab began to apply these LbL concepts to nanoparticles to address the targeting of cancer. The nanoparticle systems can be tuned to release an agent such as an inhibitor or siRNA that blocks the defense mechanisms of tumors, followed by delivery of a chemotherapy drug that can then exhibit enhanced efficacy.
https://mcmanuslab.ucsf.edu/node/268
Small interfering RNA (siRNA) is also known as short interfering RNA or silencing RNA. In the literature, synthetic siRNA constructs are generally denoted by "gene name" - siRNA (e.g. p53-siRNA), with constructs targeting the same gene distinguished by the addition of numbers after the construct name (e.g. p53-siRNA-1 and p53-siRNA-2).
https://www.ncbi.nlm.nih.gov/pubmed/28416401
Jun 20, 2017 · Polymeric nanoparticles for siRNA delivery: Production and applications. ... Chimiche e Farmaceutiche (STEBICEF), Lab of Biocompatible Polymers, University of Palermo, Via Archirafi, 32, 90129 Palermo, Italy. Gene therapy through the use of siRNA and a polymeric carrier are becoming an efficient therapeutic option to conventional pharmaceutical ...Author: Gennara Cavallaro, Carla Sardo, Emanuela Fabiola Craparo, Barbara Porsio, Gaetano Giammona
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