Simulation Of The Delivery Of Doxorubicin To Hepatoma

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Simulation of the Delivery of Doxorubicin to Hepatoma ...

    https://www.researchgate.net/publication/11867563_Simulation_of_the_Delivery_of_Doxorubicin_to_Hepatoma
    A twodimensional (2D) model, in which the delivery of doxorubicin to a hepatoma segmented of a patient CT-scan was simulated, included the extracellular binding and DNA binding of the drug (Goh et ...

Simulation of the Delivery of Doxorubicin to Hepatoma ...

    https://link.springer.com/article/10.1023/A%3A1011076110317
    Jun 01, 2001 · Purpose. To develop a two-dimensional simulation platform for the transport of doxorubicin to the hepatoma. To examine the temporal and spatial variation of doxorubicin concentration and its penetration into the tumor and the surrounding normal tissues. Methods. Simulations are carried out with Fluent/UNS using the finite volume method to obtain the interstitial fluid pressure, velocity, …Author: Yin-Min Felicia Goh, Hwai Loong Kong, Chi-Hwa Wang

Simulation of the delivery of doxorubicin to hepatoma.

    https://www.ncbi.nlm.nih.gov/pubmed/11474779
    Simulation of the delivery of doxorubicin to hepatoma. Goh YM(1), Kong HL, Wang CH. Author information: (1)Department of Chemical and Environmental Engineering National University of Singapore. PURPOSE: To develop a two-dimensional simulation platform …Author: Yin-Min Felicia Goh, Hwai Loong Kong, Chi-Hwa Wang

The effect of tumour size on drug transport and uptake in ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315397/
    Feb 17, 2017 · Drug transport and its uptake by tumour cells are strongly dependent on tumour properties, which vary in different types of solid tumours. By simulating the key physical and biochemical processes, a numerical study has been carried out to investigate the transport of anti-cancer drugs in 3-D tumour models of different sizes.Author: Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu

Physics in Medicine & Biology PAPER Related content ...

    https://iopscience.iop.org/article/10.1088/0031-9155/59/20/5987/pdf
    Several simulation studies in the past had extensively investigated the delivery of free, stealth and thermosensitive Dox to a peripheral tumor site (El-Kareh and Secomb 2000, Goh et al2001, El-Kareh and Secomb 2005, Eikenberry 2009, Zhan and Xu 2013). However, these existing models address the transport of Dox to the hepatoma ratherAuthor: Tam Nhan, Tam Nhan, Alison Burgess, Lothar Lilge, Lothar Lilge, Kullervo Hynynen, Kullervo Hynynen

Simulation of the delivery of doxorubicin to hepatoma - CORE

    https://core.ac.uk/display/48758775
    Download PDF: Sorry, we are unable to provide the full text but you may find it at the following location(s): http://scholarbank.nus.edu.sg/... (external link)Author: Y.-M.F. Goh, H.L. Kong and C.-H. Wang

Numerical simulation of the tumor interstitial fluid ...

    https://www.sciencedirect.com/science/article/pii/S0026286215000655
    Wang et al. (1999) studied BCNU delivery to the 3D reconstructed MRI images of brain tumors and estimated anticancer concentrations through in. Similarly Goh et al. (2001) developed 2D simulation for investigating transport of doxorubicin to the hepatic tumor (hepatoma) both spatially and temporally inside the tumor and its surrounding normal ...Author: Mohammad Charjouei Moghadam, Amin Deyranlou, Alireza Sharifi, Hamid Niazmand

A Mathematical Model for Thermosensitive Liposomal ...

    https://www.hindawi.com/journals/jdd/2013/172529/
    The effectiveness of anticancer treatments is often hampered by the serious side effects owing to toxicity of anticancer drugs and their undesirable uptake by healthy cells in vivo . Thermosensitive liposome-mediated drug delivery has been developed as part of research efforts aimed at improving therapeutic efficacy while reducing the associated side effect.Author: Wenbo Zhan, Xiao Yun Xu

The effect of tumour size on drug transport and uptake in ...

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172276
    Drug transport and its uptake by tumour cells are strongly dependent on tumour properties, which vary in different types of solid tumours. By simulating the key physical and biochemical processes, a numerical study has been carried out to investigate the transport of anti-cancer drugs in 3-D tumour models of different sizes. The therapeutic efficacy for each tumour is evaluated by using a ...Author: Wenbo Zhan, Wladyslaw Gedroyc, Xiao Yun Xu

New Intra-arterial Drug Delivery System for the Treatment ...

    https://clincancerres.aacrjournals.org/content/12/8/2563
    Apr 15, 2006 · Background: In the fight against cancer, new drug delivery systems are attractive to improve drug targeting of tumors, maximize drug potency, and minimize systemic toxicity. We studied a new drug delivery system comprising microspheres, with unique properties allowing delivery of large amounts of drugs to tumors for a prolonged time, thereby decreasing plasma levels. Liver tumors, …Author: Kelvin Hong, Afsheen Khwaja, Eleni A Liapi, Michael S. Torbenson, Christos S Georgiades, Jean Franco...

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