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https://www.researchgate.net/publication/11476860_Simulation_of_Methods_for_Drug_Delivery_to_the_Cochlear_Fluids
The approach has been validated in numerous experiments in which ion-selective electrodes were used to characterize the spread of marker substances in the cochlear fluids. The model incorporates the known size and geometry of cochlear fluid spaces for 6 species,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779502/
Salt AN. Simulation of methods for drug delivery to the cochlear fluids. Adv Otorhinolaryngol. 2002; 59:140–148. Salt AN, Hale S, Plontke SK. Perilymph sampling from the cochlear apex: a reliable method to obtain higher purity perilymph samples from scala tympani. J Neurosci Methods. 2006; 153:121–129. Epub ahead of print.Author: Stefan K. Plontke, Norbert Siedow, Raimund Wegener, Hans-Peter Zenner, Alec N. Salt
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751485/
Simulation of Application Strategies for Local Drug Delivery to the Inner Ear Stefan K. Plontke a and Alec N. Salt b a Tübingen Hearing Research Center and Department of Otorhinolaryngology, Head and Neck Surgery, University of Tübingen, Tübingen, Germany;Author: Stefan K. Plontke, Alec N. Salt
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1751486/
Before new drugs can be approved for clinical use, preclinical studies are necessary. This includes determining the time course and total dose of the drug within the inner ear fluids. A critically important factor in experimental studies of inner ear pharmacokinetics is the method of fluid sampling used.Author: Hartmut Hahn, Bernd Kammerer, Andre DiMauro, Alec N. Salt, Stefan K. Plontke
https://www.sciencedirect.com/science/article/pii/S0165027016301844
Comparison with existing methods(s): Controlled administration of pharmaceuticals into the cochlear apex overcomes a number of serious limitations of previously established methods such as cochlear perfusions with an injection pipette in the cochlear base: The drug concentration achieved is more precisely controlled, drug concentrations remain in scala tympani and are not rapidly washed out by cerebrospinal fluid flow, and the entire length of the cochlear spiral …Author: J.T. Lichtenhan, J. Hartsock, J.R. Dornhoffer, K.M. Donovan, A.N. Salt
https://oto.wustl.edu/items/salt-lab/
The goals of this project are to understand mechanisms of cochlear fluid regulation, with an emphasis on the pharmacokinetics of drugs in inner ear fluids. We have developed novel methods to deliver drugs to the ear quantitatively, and to measure their concentration in inner ear fluids through fluids sampling or with ion-selective electrodes.
https://www.sciencedirect.com/science/article/pii/S0928098718304226
Jan 01, 2019 · Sampling methods have been used in the past to measure drug concentrations in the cochlear fluids, but these methods provide no direct information about drug distribution in the cochlear tissues. In this work, we evaluated four fluorescent markers that simulate drug distribution in the organ of Corti after intracochlear delivery to the cochlea ...Author: Andrew M. Ayoob, Andrew M. Ayoob, Andrew M. Ayoob, Marcello Peppi, Vishal Tandon, Robert Langer, Jef...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159727/
Illustration of two methods of drug delivery from a cochlear implant device is given. (a) Prototype of a catheter designed for atraumatic insertion into the cochlea, shown inserted into a model of the cochlea and attached to a syringe. The catheter can...Author: Jeffrey T Borenstein
https://www.sciencedirect.com/science/article/pii/S101631901300013X
There are many methods that can deliver drugs to the cochlea using the route of the middle ear including passive and active drug delivery systems . Passive methods include biodegradable polymers, hydrogel-based systems, and nanoparticles.Author: Yi-Chen Pai, Chia-Fone Lee
http://www.cochlea.eu/en/cochlea/cochlear-fluids
Composition of the cochlear fluids. A remarkable characteristic of the cochlea is the unique composition of endolymph. This liquid fills the scala media, and is very rich in potassium (150mM), very poor in sodium (1mM) and almost completely lacking in calcium (20-30 µM).
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