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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142080/
Sep 28, 2014 · Silk presents a rare combination of desirable properties for sustained drug delivery, including aqueous-based purification and processing options without chemical cross-linkers, compatibility with common sterilization methods, controllable and surface-mediated biodegradation into non-inflammatory by-products, biocompatibility, utility in drug stabilization, and robust mechanical properties.Author: Tuna Yucel, Michael L. Lovett, David L. Kaplan
https://www.sciencedirect.com/science/article/pii/S0168365915001868
In the context of protein-based drug delivery systems, silk is a potentially useful natural polymer, which has been used to deliver peptide and protein molecules . Unfortunately, few studies have discussed the role of silk nanostructure in protein delivery systems.Author: Fatemeh Mottaghitalab, Mehdi Farokhi, Mohammad Ali Shokrgozar, Fatemeh Atyabi, Hossein Hosseinkhani
https://www.sciencedirect.com/science/article/pii/S0142961213015792
Silk fibroin (SF) is an exceptional drug delivery carrier with respect to stabilizing, protecting, and delivering sensitive biologics. A synopsis of thermodynamic, static light scattering, hydrophobicity probing, and nanoparticle tracking analyses served as a basis to decipher the mechanism of interaction between SF and two model proteins, protamine and polylysine.Author: Oliver Germershaus, Vera Werner, Marika Kutscher, Lorenz Meinel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401754/
Dec 12, 2018 · A promising alternative delivery method is the use of polymeric implantable devices to deliver drug compounds. Implantable drug delivery systems allow targeted and localised drug delivery and may achieve a therapeutic effect with lower concentrations of drug [3,5,6].Author: Sarah A. Stewart, Juan Domínguez-Robles, Ryan F. Donnelly, Eneko Larrañeta
https://www.hindawi.com/journals/jdd/2012/490514/
The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via spray-drying and film casting, and the release profile of the model drug naproxen sodium was evaluated.Author: Tatyana Dyakonov, Chue Hue Yang, Derek Bush, Saujanya Gosangari, Shingai Majuru, Aqeel Fatmi
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are …
https://www.medindia.net/patients/patientinfo/drug-delivery-system.htm
Drug delivery systems, is a technology using various chemicals to bind the target drugs, carry them to target organ, tissue or cell where the drug is released at a pre-determined rate.
https://www.academia.edu/2563627/SILK-_BASED_DRUG_DELIVERY_SYSTEMS
SILK- BASED DRUG DELIVERY SYSTEMS
https://gsbs.tufts.edu/facultyResearch/faculty/kaplan-david/research
Drug Delivery. Silk-based drug delivery systems are studied to exploit the all-water processing, the ability to regulate beta sheet (crystalline) content for control of lifetime in vivo (days to years), to control medical device format (e.g., coating, fibers, tablets, gels, etc.), to …
https://www.strath.ac.uk/workwithus/commercialisation/licenceopportunities/silk-baseddrugdeliverysystems/
Silk-based drug delivery systems Background. Silk’s ability to control drug release encompasses small molecular weight compounds and macromolecular protein drugs. Protein drugs are susceptible to denaturation, aggregation, proteolytic cleavage and clearance by the immune system.
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