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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824765/
Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucus layer. 1 – 3 While some chemically-modified, micro-structured surfaces have been studied in aqueous environments, 4, 5 adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with …Author: Kathleen E. Fischer, Benjamin J. Alemán, Sarah L. Tao, R. Hugh Daniels, Esther M. Li, Mark D. Bünger...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237727/
The analyzed silicon-nanowire-coated silica microparticles were shown to not disrupt the overall membrane barrier integrity in vitro, but still allow for enhanced particle adhesion and drug permeability. The results of this study demonstrate that morphology on the nanoscale is an important consideration, in addition to chemistry, when it comes ...Author: Vuk Uskoković, Phin Peng Lee, Laura A. Walsh, Kathleen E. Fischer, Tejal A. Desai
http://onlinelibrary.wiley.com/doi/10.1002/anie.201206737/full
A pratical agent for cancer therapy: Silicon nanowires (SiNWs) were employed in the design of high‐performance drug nanocarriers.The SiNWs were used as nanovectors for the delivery of an anticancer drug (DOX). SiNWs feature an ultrahigh drug‐loading capacity.
https://pubs.acs.org/doi/10.1021/nl803219f
Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.1−3 While some chemically modified, microstructured surfaces have been studied in aqueous environments,4,5 adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents ...Author: Kathleen E. Fischer, Benjamin J. Alemán, Sarah L. Tao, R. Hugh Daniels, Esther M. Li, Mark D. Bünger...
https://www.researchgate.net/publication/241158154_Silicon_nanowires_for_bioadhesive_drug_delivery
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https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.7b00106
Delivery of Cisplatin Anti-Cancer Drug from Carbon, Boron Nitride, and Silicon Carbide Nanotubes Forced by Ag-Nanowire: A Comprehensive Molecular Dynamics StudyAuthor: Esmat Mehrjouei, Hamed Akbarzadeh, Amir Nasser Shamkhali, Mohsen Abbaspour, Sirous Salemi, Pooya Abd...
https://escholarship.org/uc/item/5nr9v8zh
In beagles, nanowire- coated stainless steel particles were retained in the stomach at least ten times longer than similar controls. In mice, nanowire-coated microspheres remained in the stomach until at least 5 hours after dosing.Furthermore, the nanowire coating on these devices offers a convenient reservoir, where macromolecules may be loaded.Author: Kathleen Elizabeth Fischer
http://uskokovic.yolasite.com/resources/2012%20Biomaterials.pdf
PEGylated silicon nanowire coated silica microparticles for drug delivery across intestinal epithelium Vuk Uskokovic, Phin Peng Lee, Laura A. Walsh, Kathleen E. Fischer, Tejal A. Desai*
https://www.sciencedaily.com/releases/2015/06/150623161106.htm
Jun 23, 2015 · A new implantable drug-delivery system has been developed using nanowires that can be wirelessly controlled. The nanowires respond to an electromagnetic field generated by a …
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