We have collected information about Shrna Delivery for you. Follow the links to find out details on Shrna Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679364/
In addition, viral vectors encoding shRNAs have shown promise for in vivo delivery; however, most of these studies have utilized adenoviral delivery of shRNA, which has well-known toxic effects in the animal . Recently, adeno-associated viral vectors (AAV) have been designed with less toxicity and adequate shRNA delivery .Author: Chris B. Moore, Elizabeth H. Guthrie, Max Tze-Han Huang, Debra J. Taxman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Under in vivo conditions, siRNA and shRNA were equally effective in luciferase knockdown from 3 h to 3 days, although shRNA was significantly more potent on a molar basis . From the standpoint of transfection efficiency and delivery, siRNA poses advantages over shRNA.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.sciencedirect.com/science/article/pii/S0169409X09000969
Non-viral polymeric delivery systems, in particular those with biodegradable components, have much better safety profiles than their viral counterparts though their transfection efficiency is generally lower , , . Non-viral vehicles for delivery of siRNA and shRNA are typically cationic preparations.Author: Donald D. Rao, John S. Vorhies, Neil Senzer, John Nemunaitis
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
https://www.nature.com/articles/s41591-019-0674-1
Dec 23, 2019 · Injection of AAV–shRNA below the pial surface of the spinal cord prevents onset or ameliorates progression in a mouse model of ALS, and achieves widespread delivery …Author: Mariana Bravo-Hernandez, Takahiro Tadokoro, Takahiro Tadokoro, Michael R. Navarro, Oleksandr Platosh...
https://www.sciencedirect.com/science/article/pii/S1525001619303715
The present results confirm the capability of RVG-exosomes to deliver nucleic acids safely and specifically to the CNS in agreement with previous reports.11, 14, 15 The exosomal delivery of MCs expressing shRNA now extends the duration of knockdown achieved to over 7 weeks, compared to previous strategies using siRNAs11, 14, 16 or plasmids 16 ...Author: María Izco, Javier Blesa, Martin Schleef, Marco Schmeer, Riccardo Porcari, Raya Al-Shawi, Stephan El...
https://www.sigmaaldrich.com/catalog/genes/ABCA1
Human(19) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
http://hairpintechnologies.com/shrna-technology.html
shRNA are synthesized in the nucleus of cells, further processed and transported to the cytoplasm and then incorporated into the RNA-interfering silencing complex (RISC) for activity. Expression of shRNA in cells can incorporate different promoters and is accomplished by delivery of plasmids or through viral or bacterial vectors.
https://www.sigmaaldrich.com/catalog/product/sigma/shrna
Fully customizable shRNA sequence, vector, and lentiviral manufacturing. Select by methods other than puromycin, including neomycin (G418) and FACS via reporters. Confirm your lentiviral delivery through a fluorescent reporter. Customize your shRNA sequence. Eliminate tedious cloning and viral production.
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