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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
The study demonstrates the efficacy of CPP conjugated siRNA duplexes in targeting primary neurons in vitro and the CNS tissue in vivo (however, this is via invasive administration of the siRNA directly to the brain tissue by convection enhanced delivery). The approach has minimal toxicity towards the targeted cells, in contrast to reported ...Author: Saroj P Mathupala
https://www.sciencedirect.com/science/article/pii/S0169409X07000221
shRNA and siRNA delivery to the brain ... In DNA-based RNAi, a plasmid DNA encodes for a short hairpin RNA (shRNA). In RNA-based RNAi, a siRNA duplex is …Author: William M. Pardridge
https://www.ncbi.nlm.nih.gov/pubmed/17434235
Mar 30, 2007 · shRNA and siRNA delivery to the brain. Pardridge WM(1). Author information: (1)Department of Medicine, UCLA Warren Hall 13-164, 900 Veteran Ave., Los Angeles, CA 90024, USA. [email protected] The limiting factor in in vivo RNA interference (RNAi) is delivery.Author: William M. Pardridge
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.researchgate.net/publication/6394626_shRNA_and_siRNA_delivery_to_the_brain
shRNA and siRNA delivery to the brain Article · Literature Review (PDF Available) in Advanced Drug Delivery Reviews 59(2-3):141-52 · April 2007 with 143 Reads How we measure 'reads'
https://www.sciencedirect.com/science/article/abs/pii/S0169409X07000221
shRNA and siRNA delivery to the brain ... which results in a 90% increase in survival time in mice with intra-cranial brain cancer. Similar to the delivery of antisense agents, short interfering RNAi (siRNA) duplexes can be delivered with the combined use of targeting MAb's and avidin–biotin technology. The siRNA is mono-biotinylated in ...Author: William M. Pardridge
http://europepmc.org/articles/PMC3572210
3.5 Intravenous RNAi: brain delivery of luciferase targeted shRNA plasmid DNA. The delivery of shRNA encoding plasmid DNA to brain was initially evaluated with a luciferase brain tumor model . C6 rat glioma cells were stably transfected with a luciferase expression plasmid.
https://www.deepdyve.com/lp/elsevier/shrna-and-sirna-delivery-to-the-brain-DVbvm96Hv0
Mar 30, 2007 · shRNA and siRNA delivery to the brain shRNA and siRNA delivery to the brain Pardridge, William M. 2007-03-30 00:00:00 The limiting factor in in vivo RNA interference (RNAi) is delivery. Drug delivery methods that are effective in cell culture may not be practical in …
https://www.researchgate.net/publication/24427016_Delivery_of_small-interfering_RNA_siRNA_to_the_brain
Delivery of small-interfering RNA (siRNA) to the brain Article · Literature Review (PDF Available) in Expert Opinion on Therapeutic Patents 19(2):137-40 · March 2009 with 54 Reads
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting (In Vivo RNAi) In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro).Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA).
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