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http://intranasal.net/DeliveryTechniques/default.htm
Squeeze bottle delivery is another option for nasal drug delivery. However this technique is not able to deliver a measure dose of drug. Mucosal coverage is also dependent on the patient applying adequate pressure to the device to deliver the drug - so delivery is very variable.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953203/
Effective delivery of non-invasive positive distending pressure cannot occur in the presence of obstructed nasal passages or oropharynx. Very little evidence guides practice regarding how frequently we should preform nasal and oral suctioning.Author: Clyde J. Wright, Laurie Sherlock, Rakesh Sahni, Richard A. Polin
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https://www.optinose.com/exhalation-delivery-systems/nasal-delivery-challenges
Effective, targeted drug delivery for many therapeutic applications requires reaching the high and deep part of the nasal passages, which means drug must be delivered beyond the nasal valve and above the inferior turbinate bone to reach the broad surfaces lined by lung-like respiratory epithelium that surround sinus openings and where the nerves from the brain penetrate to carry sense of smell.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539067/
Oct 18, 2012 · Nasal delivery is the logical choice for topical treatment of local diseases in the nose and paranasal sinuses such as allergic and non-allergic rhinitis and sinusitis. The nose is also considered an attractive route for needle-free vaccination and for systemic drug delivery, especially when rapid absorption and effect are desired.Author: Per Gisle Djupesland
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