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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572212/
May 24, 2019 · Background and Objectives: Lipid-based self-nanoemulsifying drug delivery systems (SNEDDS) have resurged the eminence of nanoemulsions by modest adjustments and offer many valuable opportunities in drug delivery. Chlorpromazine, an antipsychotic agent with poor aqueous solubility—with extensive first-pass metabolism—can be a suitable candidate for the development of …Author: Jeand Baloch, Muhammad Farhan Sohail, Hafiz Shaib Sarwar, Maria Hassan Kiani, Gul Majid Khan, Sarwat...
https://www.sciencedirect.com/science/article/pii/B9780128136874000128
Formulation of self-emulsifying drug delivery systems is also an adequate approach for drugs that other formulation approaches, such as particle size reduction, salt formation or adding surfactants, did not gave satisfactory results in increasing solubility or absorption of active substance.Author: Marko Krstić, Đorđe Medarević, Jelena Đuriš, Svetlana Ibrić
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429665/
Jul 04, 2012 · Self-nanoemulsifying drug delivery systems (SNEDDS) are anhydrous homogeneous liquid mixtures, composed of oil, surfactant, drug, and/or cosolvents, which spontaneously form transparent nanoemulsion (20–200 nm droplet size) upon aqueous dilution with gentle agitation ( 1, 2 ).Author: Ahmad Abdul-Wahhab Shahba, Kazi Mohsin, Fars Kaed Alanazi
https://www.medscape.com/viewarticle/734501_6
Nov 01, 2019 · Self-nanoemulsifying drug delivery systems (SNEDDS) are nanoemulsion preconcentrates or anhydrous forms of nanoemulsion. These systems are anhydrous isotropic mixtures of oil, surfactant (s) and drug, which, when introduced into aqueous phase under conditions of gentle agitation,...
https://journal.pda.org/content/67/3/201
May 01, 2013 · The objective of the present investigation was to develop and characterize the self-nanoemulsifying drug delivery system (SNEDDS) of glimepiride, a poorly soluble drug. Solubility of glimepiride in various vehicles was determined, and ternary phase diagrams were constructed using a suitable oil, surfactant, and cosurfactant system to find out the efficient self-emulsification system.Author: Shah, Parikh Rh, Chavda, Sheth Nr
https://www.hindawi.com/journals/bmri/2018/6763057/
It could be concluded that self-nanoemulsifying drug delivery system of tetrandrine has the potential to improve the dissolution and oral bioavailability of poor water-soluble Tet. Data Availability The data used to support the findings of this study are available from the corresponding author upon request.Author: Chunxia Liu, Li Lv, Wei Guo, Lan Mo, Yaoxing Huang, Guocheng Li, Xingzhen Huang
https://www.sciencedirect.com/science/article/pii/S1773224718300546
The present research work explored the prospective of self-nanoemulsifying drug delivery system (SNEDDS) to improve the oral bioavailability of NBT and its anti-inflammatory effect. Nabumetone (NBT) is a poorly aqueous soluble drug that demonstrates low bioavailability after oral administration.Author: Sadaf Chaudhary, Mohd Aqil, Yasmin Sultana, Mohd Abul Kalam
https://www.medscape.com/viewarticle/734501_14
Oct 20, 2019 · Self-nanoemulsifying drug delivery systems (SNEDDS) are homogenous anhydrous liquid mixtures that spontaneously form oil in water nanoemulsions upon …
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