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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/self-microemulsifying-drug-delivery-system
Rubi Mahato, in Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices, 2017. 2.1.2 Microemulsions. The term microemulsion in self-microemulsifying drug delivery systems refers to small particles or droplets with the actual size less than 250 nm. These droplets exhibit high flexibility [37,38].Unlike emulsions, lipid-based micro/nanoemulsions are single optically ...
https://www.tandfonline.com/doi/pdf/10.3109/10717544.2014.896058
Self-microemulsifying drug delivery system (SMEDDS) – challenges and road ahead Shambhu Dokania* and Amita K. Joshi* Department of Pharmaceutics, NIPER Ahmedabad, C/o B.V. Patel PERD Centre, Ahmedabad, Gujarat, India Abstract Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to
https://www.sciencedirect.com/science/article/pii/S1773224719304915
Self-nanoemulsifying drug delivery system (SMEDDS) is a mixture of oil, surfactant, and cosurfactant upon mild agitation, which could enhance the solubility and oral bioavailability of drugs with poor solubility but high permeability, such as oridonin, curcumin and 5-fluorouracil [, , ].Author: Dandan Zheng, Chanmei Lv, Xiao Sun, Jinglong Wang, Zhongxi Zhao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178953/
Microemulsion is ‘a system of water, oil and amphiphile which is a single optically isotropic and thermodynamically stable liquid solution.’[] Advantage of microemulsion over other formulations is that it is easy to prepare and scale up, gives almost 100% entrapment of drug, and because of thermodynamic stability remains stable over a long period of time.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847991/
Nov 06, 2019 · In the present study, a self-microemulsion drug delivery system composed of MCT (oil phase), Cremophor RH 40 (surfactant) and ethylene glycol (co-surfactant) for the oral administration of nintedanib was developed. The characteristics of NDNB-SMEDDS, such as morphology, droplet size, stability and in vitro release were determined.Author: Hongfei Liu, Jiaao Mei, Ying Xu, Lei Tang, Daquan Chen, Yating Zhu, Shuguang Huang, Thomas J Webster...
https://www.hindawi.com/journals/isrn/2014/964051/
Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs ...Author: Samatha Akula, Aravind Kumar Gurram, Srinivas Reddy Devireddy
https://link.springer.com/article/10.1007%2Fs11051-019-4744-6
Jan 04, 2020 · Self-microemulsifying drug delivery system (SMEDDS) is a uniform and transparent solution consisting of oil phase, surfactant, co-surfactant, and a small amount of water. It could be orally administered under gastrointestinal peristalsis and spontaneously dispersed to form an oil-in-water microemulsion with typical particle sizes lower than 100 nm.Author: Beibei Yan, Yingying Ma, Juan Guo, Yancai Wang
https://www.semanticscholar.org/paper/Microemulsions-%3A-As-drug-delivery-system-Mishra-Panola/ef0ad1eb16ad9bb07458dfc5115ebd017c063840
Microemulsions are excellent candidates as potential drug delivery systems because of their improved drug solubilization, long shelf life, and ease of preparation and administration. The formulation of microemulsion for pharmaceutical use requires a thorough understanding of the properties, uses, and limitations of microemulsion.
https://www.hindawi.com/journals/jphar/2013/728425/
Sep 24, 2012 · Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker (ARB) antihypertensive agent administered orally that has absolute bioavailability of only 26% due to the poor aqueous solubility (7.75 μ g/ml). The aim of the present investigation was to develop a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral absorption of OLM.Author: Shailesh T. Prajapati, Harsh A. Joshi, Chhaganbhai N. Patel
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