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https://www.hindawi.com/journals/isrn/2014/964051/
Self-microemulsifying drug delivery systems are recent and effective approach for the augmentation of oral bioavailability of many poor water soluble drugs provided that the drug should be …Author: Samatha Akula, Aravind Kumar Gurram, Srinivas Reddy Devireddy
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/self-microemulsifying-drug-delivery-system
Self-microemulsifying drug delivery systems (SMEDDS) are designed to form an o/w microemulsion on dilution with an aqueous phase or GIT fluids upon oral administration, forming droplets in the nanosize range with high surface to volume ratio. The presence of …
https://www.tandfonline.com/doi/pdf/10.3109/10717544.2014.896058
Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to formulate poor water soluble compounds for bioavailability enhancement. However, certain limitations are associated with SMEDDS formulations which include in vivo drug precipitation,
https://www.sciencedirect.com/science/article/pii/B9780128136874000128
These systems are spontaneously emulsified in situ when exposed to gastrointestinal tract (GIT) fluids, forming oil-in-water nanoemulsions with droplet size of 100–250 nm. Self-microemulsifying drug delivery systems (SMEDDS), in comparison, contain a higher content of hydrophilic surfactants and cosurfactants, wherein lipid content is reduced.Author: Marko Krstić, Đorđe Medarević, Jelena Đuriš, Svetlana Ibrić
https://pdfs.semanticscholar.org/746a/5a974d3cea1c584e8e80b1ef4a51c952e2a2.pdf
The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility of such compounds. Self-microemulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897095/
Self-microemulsifying drug delivery systems are recent and effective approach for the augmentation of oral bioavailability of many poor water soluble drugs provided that the drug should be potent with high lipid solubility. It is well demonstrated that SMEDDS promotes lymphatic delivery of extremely hydrophobic drugs (with high octanol : water ...Author: Samatha Akula, Aravind Kumar Gurram, Srinivas Reddy Devireddy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674636/
Feb 06, 2015 · SEDDS is a stable mixture of drug, oil, surfactant, and co-surfactant; while self-microemulsifying drug delivery system (SMEDDS) is SEDDS which can form fine oil-in-water droplets with a diameter size of less than 50 nm under mild agitation of the gastrointestinal tract without the dissolution process .Author: Lan Wu, Yanli Qiao, Lina Wang, Jiahua Guo, Guocheng Wang, Wei He, Lifang Yin, Jinhua Zhao
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