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https://www.tandfonline.com/doi/pdf/10.3109/10717544.2014.896058
Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to formulate poor water soluble compounds for bioavailability enhancement. However, certain limitations are associated with SMEDDS formulations which include in vivo drug precipitation,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617838/
Jul 05, 2019 · The purposes of the present study were to: (1) develop a novel solid self-microemulsifying drug delivery system (SMEDDS) formulation of MTX via spray drying with calcium silicate as the solid carrier and (2) evaluate whether the solid SMEDDS improved the absorption and photosensitivity problems.Author: Dong Shik Kim, Jung Hyun Cho, Jong Hyuck Park, Jung Suk Kim, Eon Soo Song, Jaewook Kwon, Bhupendra R...
https://pdfs.semanticscholar.org/746a/5a974d3cea1c584e8e80b1ef4a51c952e2a2.pdf
Self-microemulsifying drug delivery (SMEDDS) is the one of the method for the improvement of oral bioavailability. SMEDDS are class of emulsion that has received particular attention as a means of enhancing oral bioavailability of poorly absorbed drugs.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674636/
Feb 06, 2015 · The drug has better antidepressant effect, achieved by acting on the 5-hydroxytryptamine receptor. However, the therapeutic effects of the drug are compromised due to its poor water solubility and lower bioavailability. Herein, a self-microemulsifying drug delivery system (SMEDDS) was developed to improve its solubility and oral bioavailability.Author: Lan Wu, Yanli Qiao, Lina Wang, Jiahua Guo, Guocheng Wang, Wei He, Lifang Yin, Jinhua Zhao
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/self-microemulsifying-drug-delivery-system
Self-microemulsifying drug delivery systems (SMEDDS) are designed to form an o/w microemulsion on dilution with an aqueous phase or GIT fluids upon oral administration, forming droplets in the nanosize range with high surface to volume ratio. The presence of …
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