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https://www.sciencedirect.com/science/article/pii/B9780323296427000059
One of the most promising areas of research in drug delivery and tissue engineering is the utilization of peptides – either physically via encapsulation into self-assembled nanostructures or through chemical conjugation to bestow self-assembling capabilities – as a biodegradable, physiologically sensitive, inherently “tunable,” and remarkably facile design platform for highly sophisticated drug delivery systems.Author: Daniel Keith, Honggang Cui
https://pubs.rsc.org/en/content/articlelanding/2013/cp/c3cp51207j#!
Self assembly of small molecules in complex supramolecular structures provides a new avenue in the development of materials for drug delivery applications. Owing to the low aqueous solubility of various drugs , an effective delivery system is often required to reach sufficient drug bioavailability and/or to facilitate clinical use.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2222591/
Dec 01, 2007 · It appears that nano drug delivery systems hold great potential to overcome some of the barriers to efficient targeting of cells and molecules in inflammation and cancer. There also is an exciting possibility to overcome problems of drug resistance in target cells and to facilitating movement of drugs across barriers such as those in the brain.Author: Sarabjeet Singh Suri, Hicham Fenniri, Baljit Singh
https://pubs.rsc.org/en/content/articlehtml/2020/tb/c9tb01610d
The self-assembled RNA-triple-helix hydrogel exhibits a higher selectivity in vitro and in vivo uptake and better controls miRNA expression than free miRNA and RNA transcripts. This well-developed gene delivery system provides a potential specific treatment to TNBCs with high selectivity.Author: Lairong Ding, Lairong Ding, Junwei Li, Junwei Li, Changrong Wu, Feng Yan, Xuemei Li, Shusheng Zhang
https://pubs.acs.org/doi/full/10.1021/acsomega.7b01871
In the recent years, DNA, lipids, peptides, and proteins have been utilized in the construction of biomolecule-based nanostructures which can be put to various applications such as biosensors, templates for growth of other functional materials, bioimaging, tissue engineering, enzymatic catalysis, gene expression, and drug delivery platform. The self-assembly process is governed by an intricate …Author: Gopal Pandit, Karabi Roy, Umang Agarwal, Sunanda Chatterjee
https://www.sciencedirect.com/science/article/pii/S0142961216305610
The eventual occurrence of self-delivery is both determined by prodrug design and self-assembly conditions such as pH, concentration, ionic strength, and kinetic factors. In prodrug self-delivery systems, drugs serve as hydrophobic or hydrophilic moieties to construct LMW (low molecular weight)...Author: Si-Yong Qin, Ai-Qing Zhang, Si-Xue Cheng, Lei Rong, Xian-Zheng Zhang
https://www.nature.com/articles/s41467-019-12848-5
Oct 24, 2019 · Here, the authors make a drug delivery system that is activated within the cell and exploits XIAP expression to cleave a linker region, resulting in the self-assembly of the system and drug …Author: Hong Wei An, Hong Wei An, Li Li Li, Yi Wang, Yi Wang, Ziqi Wang, Dayong Hou, Yao Xin Lin, Yao Xin Li...
https://pubs.acs.org/doi/abs/10.1021/acsomega.7b01871
Mar 15, 2018 · Peptide Boc-Trp-Leu-Trp-Leu-OMe self-assembles to form discrete nanospheres at a low concentration. Tryptophan side chains point outwards of the nanospheres while leucine side chains point towards the core of the nanospheres. The nanospheres fuse together to become microspheres with the increase in the peptide concentration.Author: Gopal Pandit, Karabi Roy, Umang Agarwal, Sunanda Chatterjee
https://www.hindawi.com/journals/jnm/2017/4562474/
Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and …Author: Taotao Fan, Xiaoyan Yu, Bing Shen, Leming Sun
https://www.nature.com/articles/s41467-017-01447-x
Nov 08, 2017 · For biomedical purposes, the development of self-assembled peptide nano-materials has primarily focused on the fields of regenerative medicine and …Author: Lee Schnaider, Sayanti Brahmachari, Nathan W. Schmidt, Bruk Mensa, Shira Shaham-Niv, Darya Bychenko,...
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