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https://cordis.europa.eu/project/id/278042/reporting
The idea behind the EU-funded SADEL (Scaffolds for alternative delivery) project was to exploit the Nanofitin technology for the delivery of antibodies. This is based on the Sac7d protein scaffold from the hyperthermophilic Sulfolobus acidocaldarius, which is encountered in sulphur-rich hot acid springs.
https://www.affilogic.com/sadel
Taking advantage of the Nanofitin protein scaffold, the SADEL project consisted of developing a blocking protein therapeutic deliverable orally for the treatment of Inflammatory Bowel Diseases. The clinically validated target chosen, TNF-alpha, is a cytokine considered a key regulator of immune cells and involved in systemic inflammation.
https://www.sciencedirect.com/science/article/pii/S0014305719318531
Drug delivery scaffolds are smart alternatives to conventional formulations and allow for controlled spatiotemporal releases of active compounds. In several fields of human health, various methods have emerged with natural and synthetic polymers that make the fabrication of new polymer scaffolds …Author: Italo Rodrigo Calori, Gustavo Braga, Priscila da Costa Carvalho de Jesus, Hong Bi, Antonio Claudio T...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309225/
Scaffold-based subcutaneous implants present a novel approach to mRNA delivery and may have the potential to finely tune local immune response. Porous scaffolds have been used to achieve sustained release of multiple factors, whereas providing a temporary residence and appropriate microenvironment for cell interaction .Author: Ruying Chen, Hong Zhang, Jingxuan Yan, James D. Bryers
https://www.nature.com/articles/s41434-018-0040-9
Sep 21, 2018 · Here, we report a novel way to use implantable porous scaffolds as a local gene delivery depot to enhance mRNA vaccine immunization in vitro, and in vivo when compared with conventional bolus injections. We first evaluated transfection efficiencies of single-stranded mRNA condensed and charge neutralized with two lipids...Author: Ruying Chen, Hong Zhang, Jingxuan Yan, James D. Bryers
https://www.sciencedirect.com/science/article/pii/S1740674918300404
In response, the protein engineering community has begun to explore alternative high-binding protein scaffolds as antibody mimics. In this short review I will summarise the generation, modification, and application of emerging antibody fragments and synthetic antibody mimics, with a …Author: Daniel A. Richards
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