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https://www.ncbi.nlm.nih.gov/pubmed/19536364
SASP gene delivery: a novel antibacterial approach. ... SASP, or Small, Acid-soluble Spore Protein(s), inactivate bacterial DNA in a non-sequence-specific manner so their activity is unaffected by DNA mutations. Selected pathogens can be targeted, avoiding the normal flora. A Staphylococcus aureus-targeted SASPject, PT1.2, developed for the ...Author: Fairhead H
https://www.researchgate.net/publication/26301285_SASP_gene_delivery_A_novel_antibacterial_approach
SASP gene delivery: A novel antibacterial approach. ... injecting a gene encoding an antibacterial protein, SASP, into target bacteria. SASP, or Small, Acid-soluble Spore Protein(s), inactivate ...
https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=3&p_RefId=1367708&p_IsPs=N
SASP gene delivery: A novel antibacterial approach Fairhead, H. Antibiotic resistance is a global problem, and with bacteria having developed resistance to all approved antibacterial agents there is a growing need for innovative solutions.
http://files.constantcontact.com/27b12914101/25021cfe-35f6-4b90-9eb4-feb014aa19f3.pdf
Background: SASP is a unique antibacterial protein that halts DNA replication and gene expression. Found in bacterial spores, SASP binds to bacterial DNA in a non-sequence specific manner, making resistance extremely unlikely, and rapidly kills ... SASP gene delivery: A novel antibacterial approach. Drug News Perspectives 22(4): 197 2.
http://www.phicotx.co.uk/wp-content/uploads/2014/12/F1550.pdf
Background: Phico’sSASPject technology uses a synthetic biology approach to create nano-delivery vehicles (NDV), capable of delivering a SASP gene expression system to target bacteria. For novel antibacterials to be successful it is critical that they demonstrate a low propensity for the development of resistance. The unique
https://www.future-science.com/doi/10.4155/tde-2017-0040
Recent advances in therapeutic delivery systems of bacteriophage and bacteriophage-encoded endolysins. ... SASP gene delivery: a novel antibacterial approach. ... a novel approach to enhance phage biodistribution. J. Virol. Methods 236, ...Author: Hollie Hathaway, Scarlet Milo, J Mark Sutton, Toby A Jenkins
https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(15)00466-1/fulltext
Feb 01, 2016 · A broader approach to address bacterial infection is needed. In this Review, we discuss alternatives to antibiotics, which we defined as non-compound approaches (products other than classic antibacterial agents) that target bacteria or any approaches that target the host. ... SASP gene delivery: a novel antibacterial approach. Drug News ...Author: Lloyd Czaplewski, Richard Bax, Martha Clokie, Mike Dawson, Heather Fairhead, Vincent A Fischetti, Si...
http://www.phicotx.co.uk/wp-content/uploads/2014/12/F1548.pdf
SASP binding is DNA sequence-independent and thus mutations have no impact upon SASP activity. Phico’sSASPject technology uses a synthetic biology approach to create nano-delivery vehicles (NDV), capable of delivering a SASP gene expression system to target bacteria. SASP production in situ in target cells is rapidly bactericidal.
https://www.researchgate.net/profile/Heather_Fairhead2
SASP gene delivery: A novel antibacterial approach. ... A Novel Antibacterial Protein which Shows Rapid Bactericidal Activity Against MRSA in the Presence of Other Antibiotics ... SASP: A Novel ...
https://www.ncbi.nlm.nih.gov/pubmed/19006597
To combat resistance, the development of new treatment options is required. Recent advances in technology have aided in the discovery of novel antibacterial agents, specifically through genome mining for novel natural product biosynthetic gene clusters and improved small molecule high-throughput screening methods.Author: Patricia L. Taylor, Gerard D. Wright
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