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https://health.ucsd.edu/news/releases/Pages/2014-11-17-rnai-drug-delivery.aspx
Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery — it is extremely difficult to get RNAi drugs inside the cells in which they are needed.
https://www.bccresearch.com/market-research/biotechnology/rnai-drug-delivery.html
This BCC Research report provides an in-depth assessment of recent progress and future opportunities for RNA interference (RNAi) players in major therapeutic and drug delivery areas, including infectious diseases, cancer, inflammation/immune dysfunction, central nervous system (CNS) disorders, and cardiology/metabolism.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · In theory, hepatocytes are attractive targets for siRNA due to the relatively easy delivery secondary to the passive targeting features of nano-sized drug carriers to liver. Conjugation or complexation of siRNA to antibody increases the specificity of siRNA delivery …Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://phys.org/news/2018-08-rna-drug.html
Aug 17, 2018 · Small interfering RNA sounds like something from a science fiction novel rather than a revolutionary type of medicine. But this odd-sounding new drug offers a …Author: Thomas Schmittgen
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · RNA drug delivery with RBCEVs shows highly robust microRNA inhibition and CRISPR–Cas9 genome editing in both human cells and xenograft …Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://www.ddw-online.com/therapeutics/p322575-current-trends-in-rna-therapeutics-development.html
RNA drug development efforts have primarily focused on four modalities: 1) mRNA vaccines for cancer and infectious disease. 2) In vitro transcribed (IVT) mRNAs to replace or supplement proteins. 3) Antisense RNAs, or RNA interference (RNAi) via miRNAs and siRNAs, to partially or completely turn off gene expression.
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