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https://www.sciencedirect.com/science/article/pii/S1818087614000646
The currently developed siRNA delivery systems for cancer therapy can be divided into four categories: chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery systems, and others (exosomes, RNAi-microsponges, oligonucleotide nanoparticles). 4.1. Chemical modifications of anti-cancer siRNAAuthor: Cong-fei Xu, Jun Wang
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
For efficient siRNA delivery, cationic materials that include additional stabilizing interactions (e.g. hydrophobic modifications) and utilize architecture (e.g. well defined polymer morphology, cross-linking) are the most promising. Outside of the classical drug delivery systems, there are also new strategies to develop siRNA therapeutics.Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854016/
Nov 04, 2013 · The expansion of novel nanoparticles for drug delivery is an exciting and challenging research filed, in particular for the delivery of emerging cancer therapies, including small interference RNA (siRNA) and microRNA (miRNAs)-based molecules. In this review, we focus on the currently available drug delivery systems for anticancer agents.Author: Mónica Rivera Díaz, Pablo E. Vivas-Mejia
https://drug-dev.com/global-delivery-market-advanced-drug-delivery-systems-mab-rnai-breaking-the-blood-brain-barrier/
There has been immense progress in the field of nanotechnology for drug delivery, and efforts have been dedicated to the development of nanoparticle-based RNAi delivery systems. A carefully engineered, multifunctional nanocarrier with targeting capabilities is needed to address the delivery …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Due to the similar physicochemical properties between DNA and siRNA, carriers developed for DNA have also been applied to siRNA. These carriers can be broadly divided into two categories, i.e., viral and non-viral. Readers are referred to a recent review on viral delivery systems for RNAi . In part due to the potential toxicities associated ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://link.springer.com/article/10.1007%2Fs10555-017-9717-6
Dec 14, 2017 · Over the past decade, great efforts have been undertaken to develop RNAi delivery systems that overcome these obstacles. This review presents an update on current progress in the therapeutic application of RNAi with a focus on cancer therapy and strategies for optimizing delivery systems, such as lipid-based nanoparticles.Author: Xiuhui Chen, Xiuhui Chen, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Xianchao Kong, Gabriel L...
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · RNA drug delivery with RBCEVs shows highly robust microRNA inhibition and CRISPR–Cas9 genome editing in both human cells and xenograft mouse models, with no observable cytotoxicity. RNA delivery ...Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://www.grandviewresearch.com/industry-analysis/global-antisense-and-rni-therapeutic-market
However, there are many challenges associated with the emerging antisense technology (and RNAi). One of the prominent bottleneck is the drug delivery to the intended site. Drug delivery to the nervous tissues is one of the problems as the drug has to pass the blood-brain barrier. Companies are coming up with solutions to overcome these challenges.
https://www.genengnews.com/uncategorized/rnai-therapeutics-to-the-liver-and-beyond/
Mar 14, 2018 · Also, progress in RNAi is being sustained by improvements in drug delivery systems. Not Just for Hepatitis B A major player in RNAi therapies is Arrowhead Pharmaceuticals.
https://news.yahoo.com/global-markets-drug-delivery-cancer-173000014.html
Mar 12, 2020 · Drug delivery systems for cancer. Antisense, RNAi and gene therapy for cancer. Delivery strategies according to cancer type and location. Cancer drug delivery markets. Companies. Drug delivery remains a challenge in management of cancer. Approximately 12.5 million new cases of cancer are being diagnosed worldwide each year and considerable ...
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