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https://www.sciencedirect.com/science/article/pii/S0168365914005677
2.8. RNAi delivery strategies employed in the current clinical pipeline. The evolution of the RNAi clinical pipeline reflects the aforementioned advantages of systemic over local RNAi delivery. Just 3 years following the discovery of RNAi occurring in mammalian cells , in 2004 the first RNAi therapeutics candidate entered clinical development ...Author: D. Haussecker
https://www.sciencedirect.com/science/article/pii/S0273230015300507
RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting ... The delivery of products that utilize the RNAi mode of action as a biocontrol may occur as spray, drench, or granular applications. ... A FIFRA-SAP on “RNAi technology as a pesticide: Problem formulation for human health and ecological risk ...Author: James H. Sherman, Tichafa Munyikwa, Stephen Y. Chan, Jay S. Petrick, Kenneth Whitaker Witwer, Suprat...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · RNA interference (RNAi) ... (<30 nucleotides) do not have this problem . ... Readers are referred to a recent review on viral delivery systems for RNAi . In part due to the potential toxicities associated with viral vectors, non-viral vectors have become increasingly popular alternatives.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
http://veritasbiollc.com/rna-delivery-technology/
Delivery of RNAi: A novel approach for delivery of Nucleic Acids to Cells. Provides a solution to the rate-limiting step in the delivery of RNA-based drugs (RNAi, miRNA, mRNA).. Background: Although, RNAi and antisense technologies have the potential to be developed as targeted therapeutics, delivery of these nucleic acid molecules has been a challenge.
https://igtrcn.org/issues-in-rnai-delivery-and-development/
Nov 19, 2014 · Hausseker (2014) has recently written a brief review entitled “Current issues of RNAi therapeutics delivery and development” published in the Journal of Controlled Release that is a nice summary of the current state of the art in RNAi delivery in mammalian systems with specific interest in therapeutic treatments of disease in humans.
https://www.alliedacademies.org/articles/rethinking-delivery-viral-vectors-and-rna-interference-7646.html
Rethinking Delivery: Viral Vectors and RNA Interference, Jens Kurreck. Home A-Z Journals; About . FAQ History. ... specific and well-tolerated delivery in RNAi applications. ... this seems to be more of a problem for scientific studies than for medical applications of the technology. While it is important to ascribe the effects of depletion of ...Author: Jens Kurreck
https://www.pbs.org/wgbh/nova/article/rnai-cure/
Jul 01, 2005 · This direct delivery helps ensure that "naked" RNAi drugs—short strands of RNA that aren't packaged and protected in membranes and which quickly …
https://www.researchgate.net/publication/336161535_Rekindling_RNAi_Therapy_Materials_Design_Requirements_for_In_Vivo_siRNA_Delivery
The primary obstacle to realization of RNAi therapy has been the delivery of oligonucleotide payloads. Therefore, the main aims is to identify and describe key design features needed for nanoscale ...
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