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https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0683-y
Jul 28, 2017 · Since the expression and functionality of siRNAs and miRNAs are significantly reduced in cancer cells, RNAi is an attractive target for the development of innovative therapeutics. However, the main obstacle to achieving gene silencing in vivo using RNAi techniques is the delivery of therapeutic RNAi molecules . Thus, the clinical application of ...Author: Yong Xin, Min Huang, Wen Wen Guo, Qian Huang, Long zhen Zhang, Guan Jiang
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The currently developed siRNA delivery systems for cancer therapy can be divided into four categories: chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery systems, and others (exosomes, RNAi-microsponges, oligonucleotide nanoparticles). 4.1. Chemical modifications of anti-cancer siRNAAuthor: Cong-fei Xu, Jun Wang
https://www.pbs.org/wgbh/nova/article/rnai-cure/
Jul 01, 2005 · Local delivery also makes it less likely that the drugs will have unanticipated, harmful effects elsewhere in the body. ... leukemia may be among the first forms of …
https://molecular-cancer.biomedcentral.com/track/pdf/10.1186/s12943-017-0683-y?site=molecular-cancer.biomedcentral.com
expected to play important roles in the delivery of RNAi molecules for cancer therapeutics. Keywords: Nanocarriers, RNAi, siRNA, miRNA, Cancer therapy, Gene therapy Background Cancer is a major public health problem around the world [1], and the world-wide incidence of cancer con-tinues to increase [2]. The world cancer rate is expected
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137419/
Aug 10, 2014 · Although a huge budget is allocated on cancer research every year, cancer remains the second global cause of death. And, exclusively, less than 50% of patients afflicted with advanced cancer live one year subsequent to standard cancer treatments. RNA interference (RNAi) is …Author: Mansoori B, Sandoghchian Shotorbani S, Baradaran B
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677667/
Jul 30, 2019 · Intracytoplasmic delivery of siRNA by peptide nanoparticles in pancreatic and colorectal cancer is spatially separate from lysosomes and highly efficient. (A) Confocal microscopy demonstrates diffuse cell uptake of fluorescent tagged siRNA bearing NPs (pink) at …Author: Matthew S. Strand, Bradley A. Krasnick, Hua Pan, Xiuli Zhang, Ye Bi, Candace Brooks, Christopher Wet...
https://www.prnewswire.com/news-releases/global-markets-for-drug-delivery-in-cancer-forecast-to-2028---includes-coverage-on-antisense-rnai-and-gene-therapy-for-cancer-301022330.html
Global Markets for Drug Delivery in Cancer, Forecast to 2028 - Includes Coverage on Antisense, RNAi and Gene Therapy for Cancer
https://www.sciencedirect.com/science/article/pii/S0142961216302782
RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer Author links open overlay panel Taral R. Lunavat a 1 Su Chul Jang a b 1 Lisa Nilsson c Hyun Taek Park b Gabriela Repiska a Cecilia Lässer a Jonas A. Nilsson c Yong Song Gho a b Jan Lötvall aAuthor: Taral R. Lunavat, Su Chul Jang, Su Chul Jang, Lisa Nilsson, Hyun Taek Park, Gabriela Repiska, Cecili...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Delivery materials. Broadly speaking, RNA delivery can be mediated by viral and non-viral vectors. For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo []—however, this section will focus mainly on the development of non-viral materials (Table 1).Of the non-viral RNA delivery vehicles, nanoparticles are perhaps ...Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.genengnews.com/magazine/153/mirna-rnai-delivery-and-applications/
Mar 01, 2011 · The key requirement for the development of an effective cancer treatment is the systemic tumor-targeted delivery of the therapeutic molecules to both primary and metastatic tumors, bypassing the ...
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