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https://www.ddw-online.com/therapeutics/p322575-current-trends-in-rna-therapeutics-development.html
Furthermore, the new chemistries confer drug-like properties to RNA, reduce immune stimulation, maximise on-target potency and prolong the duration of the drug. Delivery of RNA therapeutics. RNA-based therapeutics must be delivered to the target cell and enter the cell to be active (8) (Figure 1).
https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · RNA drug delivery with RBCEVs shows highly robust microRNA inhibition and CRISPR–Cas9 genome editing in both human cells and xenograft mouse models, with no observable cytotoxicity. RNA delivery ...Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://www.modernatx.com/mrna-technology/mrna-platform-enabling-drug-discovery-development
They are organized around key disciplines and work in an integrated fashion to advance knowledge surrounding mRNA science and solve for challenges that are unique to mRNA drug development. Some of these disciplines include mRNA biology, chemistry, formulation & delivery…
https://www.ncbi.nlm.nih.gov/pubmed/29907766
Jun 15, 2018 · Efficient RNA drug delivery using red blood cell extracellular vesicles. ... Most of the current methods for programmable RNA drug therapies are unsuitable for the clinic due to low uptake efficiency and high cytotoxicity. Extracellular vesicles (EVs) could solve these problems because they represent a natural mode of intercellular ...Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://cen.acs.org/business/start-ups/mRNA-disrupt-drug-industry/96/i35
Messenger RNA technology promises to turn our bodies into medicine-making factories. ... And even if the molecule makes it into the cell—another challenge that has long vexed drug delivery ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004015/
Jun 15, 2018 · In this study, we scaled up the generation of large amounts of RBCEVs for the delivery of therapeutic RNAs. RBCEV-mediated RNA drug delivery led to efficient microRNA knockdown and gene knockout with CRISPR–Cas9 genome editing in leukemia and breast cancer cells in vitro and in vivo, without any observable cytotoxicity.Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Delivery materials. Broadly speaking, RNA delivery can be mediated by viral and non-viral vectors. For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo []—however, this section will focus mainly on the development of non-viral materials (Table 1).Of the non-viral RNA delivery vehicles, nanoparticles …Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The attitude of big pharmaceutical companies to RNAi drugs has also become over-optimistic. In summary, a good delivery system is the key to siRNA drug development. Once research into siRNA drug delivery systems makes a significant breakthrough, siRNA will occupy a strong position in the drug market, especially the anti-cancer drug market.Author: Cong-fei Xu, Jun Wang
https://rna-drugdiscovery.com/
*The 2019 edition of this event has now run. Thanks to all the participants!* At a time when the previously untapped drug discovery opportunity promised within RNA opens up, the 2nd RNA- Targeted Drug Discovery Summit returned to reunite the leading minds from large pharma, innovative biotech and KOLs of academia to discuss unique discovery and development challenges that must be overcome for ...
https://cancer.osu.edu/news/rna-nanoparticles-may-improve-the-solubility-delivery-and-safety-of-cancer-chemotherapy#!
Two studies led by researchers at the OSUCCC – James suggest that RNA nanoparticles may vastly improve the solubility, delivery and safety of two
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