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https://www.nature.com/articles/s41467-018-04791-8
Jun 15, 2018 · RNA delivery for disease treatment often has low uptake efficiencies and cytotoxicity. Here the authors produce extracellular vesicles from red blood cells for in …Author: Waqas Muhammad Usman, Tin Chanh Pham, Yuk Yan Kwok, Luyen Tien Vu, Victor Ma, Boya Peng, Yuen San Ch...
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo —however, this section will focus mainly on the development of non-viral materials (Table 1). Of the non-viral RNA delivery vehicles, nanoparticles are perhaps the most studied.Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://exopharm.com/exosomes-as-drug-delivery-vehicles/
Jan 01, 2017 · And exosomes appear to be the perfect drug delivery system. Many synthetic nanoparticles have been trialled as drug delivery vehicles, but very few have received FDA approval for human use, Duxin Sun from the University of Michigan, US, wrote recently in the Nature journal Acta Pharmacologica Sinica 1.
https://pubs.acs.org/doi/10.1021/nn502125h
Precise Engineering of siRNA Delivery Vehicles to Tumors Using Polyion Complexes and Gold Nanoparticles. ... on the Distribution of Hydrophobic Segments in the Chains of Amphiphilic Cationic Polymers for Small Interfering RNA Delivery.Author: Hyun Jin Kim, Hiroyasu Takemoto, Yu Yi, Meng Zheng, Yoshinori Maeda, Hiroyuki Chaya, Kotaro Hayashi,...
https://www.nature.com/articles/s41467-019-12275-6
Sep 24, 2019 · LNPs represent one of the most potent RNA delivery vehicles in vivo, and are currently being tested in human clinical trials. However, the fate of the RNA …Author: Marco Maugeri, Muhammad Nawaz, Alexandros Papadimitriou, Annelie Angerfors, Alessandro Camponeschi, ...
https://www.liebertpub.com/doi/10.1089/nat.2018.0726
Jun 01, 2018 · Preclinically, new systems are being developed specifically for mRNA. There remain key obstacles to be overcome. Dose limiting toxicities still tend to be associated with delivery vehicles for mRNA therapeutics and it would benefit the field if more investigators disclosed the therapeutic index of novel systems in preclinical species.Author: Matthew G. Stanton
https://www.sciencedirect.com/science/article/pii/S0169409X16302046
Recent progress in RNA biology has broadened the scope of therapeutic targets of RNA drugs for cancer therapy. However, RNA drugs, typically small interfering RNAs (siRNAs), are rapidly degraded by RNases and filtrated in the kidney, thereby requiring a delivery vehicle …Author: Hyun Jin Kim, Ahram Kim, Kanjiro Miyata, Kazunori Kataoka
https://www.liebertpub.com/doi/10.1089/hum.2008.928
Although challenges remain, delivery represents the main hurdle for faster and broader development of siRNA therapeutics. In this review, a summary of the advances in in vivo siRNA delivery is presented and discussed. Multiple different delivery approaches have demonstrated success ranging from the relative simplicity of direct local ...Author: Antonin R. de Fougerolles
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