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https://science.sciencemag.org/content/301/5634/839.full
Aug 08, 2003 · The importance of retrograde delivery was accentuated by the finding of the significantly reduced effects of IGF-1 delivered by lentivirus, a virus that is not transported efficiently , when compared to the effects of IGF-1 delivered by AAV. The marked effects of IGF-1 on onset and survival are accompanied by robust survival and preserved morphology of MNs and decreased gliosis.Author: Brian K. Kaspar, Jerònia Lladó, Nushin Sherkat, Jeffrey D. Rothstein, Fred H. Gage
https://science.sciencemag.org/content/sci/301/5634/839.full.pdf
Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model BrianK.Kaspar,1 Jero`niaLlado´,2*NushinSherkat,1 JeffreyD.Rothstein,2 FredH.Gage1† Amyotrophiclateralsclerosis(ALS)isaprogressive,lethalneuromuscular diseasethatisassociatedwiththedegenerationofspinalandbrainstem motorneurons…Author: Brian K. Kaspar, Jerònia Lladó, Nushin Sherkat, Jeffrey D. Rothstein, Fred H. Gage
https://jhu.pure.elsevier.com/en/publications/retrograde-viral-delivery-of-igf-1-prolongs-survival-in-a-mouse-a-4
Aug 08, 2003 · title = "Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model", abstract = "Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neuromuscular disease that is associated with the degeneration of spinal and brainstem motor neurons, leading to atrophy of limb, axial, and respiratory muscles.Author: Brian K. Kaspar, Jerònia Lladó, Nushin Sherkat, Jeffrey D. Rothstein, Fred H. Gage
https://www.researchgate.net/publication/10622006_Retrograde_Viral_Delivery_of_IGF-1_Prolongs_Survival_in_a_Mouse_ALS_Model
Delivery of AAV– IGF-1 at disease onset by retrograde transport extends survival and delays motor decline. ( A ) The cumulative probability of survival in symptomatic G93A SOD1 mice injected with AAV-GDNF (blue), AAV–IGF-1 (red), or AAV-GFP (green) at 90 days of age.
http://adsabs.harvard.edu/abs/2003Sci...301..839K
Abstract Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neuromuscular disease that is associated with the degeneration of spinal and brainstem motor neurons, leading to atrophy of limb, axial, and respiratory muscles.
http://europepmc.org/abstract/MED/12907804
Sep 01, 2003 · Neurotrophic factors are candidates for therapeutic evaluation in ALS. Although chronic delivery of molecules to the central nervous system has proven difficult, we recently discovered that adeno-associated virus can be retrogradely transported efficiently from muscle to …Author: Brian K. Kaspar, Jerònia Lladó, Nushin Sherkat, Jeffrey D. Rothstein, Fred H. Gage
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.7254
eports retrograde viral delivery mouse al model igf-1 prolongs survival amyotrophic lateral sclerosis gene mutation insulin-like growth factor pathological characteristic central nervous system respiratory muscle adeno-associated virus brainstem motor neuron therapeutic evaluation neurotrophic factor chronic delivery delay disease progression overt disease symptom spinal cord superoxide dismutase-1 …
https://www.nature.com/articles/3302204
Jan 15, 2004 · (a) Intramuscular delivery of LV-IGF-1 leads to a muscle-restricted expression of IGF-1 that might be retrogradely transported to motor neurons (MN) and counteracts neuronal loss in ALS transgenic mice. In this case, the IGF-1 protective effect is less robust than in (b),...Author: C Raoul, P Aebischer
https://www.alzforum.org/papers/retrograde-viral-delivery-igf-1-prolongs-survival-mouse-als-model
Jul 31, 2009 · Kaspar BK, Lladó J, Sherkat N, Rothstein JD, Gage FH.Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science. 2003 Aug …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835088/
Feb 27, 2009 · Thus far, the most widespread rAAV-mediated transduction of the spinal cord has been through direct injections of the red nucleus 27 or peripheral injections into muscle, 28 resulting in anterograde or retrograde transport, respectively (see Figure 1).Author: Fredric P Manfredsson, Aaron C Rising, Ronald J Mandel
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