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https://science.sciencemag.org/content/301/5634/839.full
Aug 08, 2003 · AAV– IGF-1 delivery clearly delayed loss of MNs and also increased muscle mass. Those two effects alone could be responsible for the increased survival in mice. However, lentiviral delivery of IGF-1 to muscle, without retrograde transport, only produced a modest effect in survival.Author: Brian K. Kaspar, Jerònia Lladó, Nushin Sherkat, Jeffrey D. Rothstein, Fred H. Gage
https://www.researchgate.net/publication/10622006_Retrograde_Viral_Delivery_of_IGF-1_Prolongs_Survival_in_a_Mouse_ALS_Model
Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model Article (PDF Available) in Science 301(5634):839-42 · September 2003 with 313 Reads How we measure 'reads'
https://science.sciencemag.org/content/sci/301/5634/839.full.pdf
Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model BrianK.Kaspar,1 Jero`niaLlado´,2*NushinSherkat,1 JeffreyD.Rothstein,2 FredH.Gage1† Amyotrophiclateralsclerosis(ALS)isaprogressive,lethalneuromuscularAuthor: Brian K. Kaspar, Jerònia Lladó, Nushin Sherkat, Jeffrey D. Rothstein, Fred H. Gage
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.7254
BibTeX @MISC{Kaspar_reports, author = {Brian K. Kaspar and Jerònia Lladó and Nushin Sherkat and Jeffrey D. Rothstein and Fred H. Gage}, title = {R EPORTS Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model}, year = {}}
http://adsabs.harvard.edu/abs/2003Sci...301..839K
Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model: Authors: Kaspar, Brian K.; Lladó, Jerònia; ... Abstract Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neuromuscular disease that is associated with the degeneration of spinal and brainstem motor neurons, leading to atrophy of limb, axial, and respiratory ...
https://jhu.pure.elsevier.com/en/publications/retrograde-viral-delivery-of-igf-1-prolongs-survival-in-a-mouse-a-4
Aug 08, 2003 · title = "Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model", abstract = "Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neuromuscular disease that is associated with the degeneration of spinal and brainstem motor neurons, leading to atrophy of limb, axial, and respiratory muscles.Author: Brian K. Kaspar, Jerònia Lladó, Nushin Sherkat, Jeffrey D. Rothstein, Fred H. Gage
https://www.alzforum.org/papers/retrograde-viral-delivery-igf-1-prolongs-survival-mouse-als-model
Jul 31, 2009 · Kaspar BK, Lladó J, Sherkat N, Rothstein JD, Gage FH.Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science. 2003 Aug …
http://europepmc.org/abstract/MED/12907804
Sep 01, 2003 · Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. (PMID:12907804) Abstract Citations ... Although chronic delivery of molecules to the central nervous system has proven difficult, we recently discovered that adeno-associated virus can be retrogradely transported efficiently from muscle to motor neurons of the spinal ...Author: Brian K. Kaspar, Jerònia Lladó, Nushin Sherkat, Jeffrey D. Rothstein, Fred H. Gage
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737251/
Delivery of AAV-IGF-1 to the DCN resulted in motor neuron protection and increased life span. AAV1-IGF-1 and AAV2-IGF-1 were tested for their ability to enhance motor neuron survival in SOD1 G93A mice compared with control AAV1-GFP and AAV2-GFP when injected at disease onset (88–90 days old). All regions of the spinal cord were evaluated at 110 days of age for the number of ChAT positive cells.Author: James C Dodge, Amanda M Haidet, Amanda M Haidet, Wendy Yang, Marco A Passini, Mark Hester, Jennifer ...
https://www.nature.com/articles/nature02544?error=cookies_not_supported&code=54dfb930-4f48-4ae4-8a70-fcd41ff763b0
May 27, 2004 · VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model ... J., Sherkat, N., Rothstein, J. & Gage, F. Retrograde viral delivery of IGF-1 prolongs survival in ...
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