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https://www.nature.com/articles/nmat998
Oct 19, 2003 · A biodegradable device that could provide multi-dose drug delivery would be advantageous for long-term treatment of conditions requiring pulsatile drug release. In this work, biodegradable polymeric microchips were fabricated that released four pulses of radiolabelled dextran, human growth hormone or heparin in vitro.Author: Amy C. Richards Grayson, Amy C. Richards Grayson, Insung S. Choi, Betty M. Tyler, Paul P. Wang, Henr...
https://www.sciencedirect.com/science/article/pii/S0168365907004075
Nov 06, 2007 · A resorbable, multi-reservoir polymer microchip drug delivery system has been tested against a tumor model. The microchip reservoirs were loaded with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). BCNU was more stable at 37 °C within the microchip compared to a uniformly impregnated polymeric wafer (70% intact drug vs . 38%, at 48 h).Author: Grace Y. Kim, Grace Y. Kim, Betty Mae Tyler, Malinda M. Tupper, Jeffrey M. Karp, Robert S. Langer, H...
https://www.ncbi.nlm.nih.gov/pubmed/17884232
Nov 06, 2007 · A resorbable, multi-reservoir polymer microchip drug delivery system has been tested against a tumor model. The microchip reservoirs were loaded with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). BCNU was more stable at 37 degrees C within the microchip compared to a uniformly impregnated polymeric wafer (70% intact drug vs. 38%, at 48 h).Author: Grace Y. Kim, Grace Y. Kim, Betty Mae Tyler, Malinda M. Tupper, Jeffrey M. Karp, Robert S. Langer, H...
https://www.researchgate.net/publication/9006689_Multi-pulse_drug_delivery_from_a_resorbable_polymeric_microchip_device
Multi-pulse drug delivery from a resorbable polymeric microchip device. ... The present paper also focuses on the main features of important polymer system used in drug delivery, as well as, the ...
https://www.academia.edu/13462682/Multi-pulse_drug_delivery_from_a_resorbable_polymeric_microchip_device
Multi-pulse drug delivery from a resorbable polymeric microchip device
https://www.researchgate.net/publication/5959407_Resorbable_Polymer_Microchips_Releasing_BCNU_Inhibit_Tumor_Growth_in_the_Rat_9L_Flank_Model
Resorbable Polymer Microchips Releasing BCNU Inhibit Tumor Growth in the Rat 9L Flank Model. Sustained local delivery of single agents and controlled delivery of multiple chemotherapeutic agents are sought for the treatment of brain cancer.
https://www.hindawi.com/journals/bmri/2016/1743472/
In 1998, the US Patent “Microchip Drug Delivery Devices” was awarded to Santini Jr. et al., which first outlined the parameters of a multireservoir microchip system with an active release system . In 1999, Santini Jr. et al. debuted the first electrochemically activated drug delivery microchip .Author: Adam E. M. Eltorai, Henry Fox, Emily McGurrin, Stephanie Guang
http://news.mit.edu/2015/implantable-drug-delivery-microchip-device-0629
Jun 29, 2015 · Now Microchips Biotech will begin co-developing microchips with Teva Pharmaceutical, the world’s largest producer of generic drugs, to treat specific diseases, with licensing potential for other products. Teva paid $35 million up front, with additional milestone payments as the device goes through clinical trials before it hits the shelves.
http://www.thepharmajournal.com/vol1Issue10/Issue_dec_2012/1.1.pdf
Microchip drug delivery system is the most wonderful system of delivering the drug for a great span of time without the intervention of the patient to whom it is fixed. It consists of varied number of sockets
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