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https://www.tandfonline.com/doi/abs/10.1080/10837450.2018.1484766
Dec 28, 2017 · Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery …Author: Trusha J. Purohit, Sara M. Hanning, Zimei Wu
http://globalresearchonline.net/journalcontents/v21-1/13.pdf
The rectum offers a relatively constant environment for drug delivery provided the drug is presented in a well absorbable form. The rate controlled dosage forms resulting in constant steady-state concentration of drugs in plasma selectedFile Size: 359KB
https://www.pharmatutor.org/articles/discussion-novel-rectal-drug-delivery-systems-recent-review
Rectal drug delivery is an efficient alternate to oral and parenteral route of administration in partial avoidance of first pass metabolism and protein peptide drug delivery. This route allows both local and systemic therapy of drugs.
https://www.researchgate.net/publication/313161191_RECTAL_DRUG_DELIVERY_SYSTEMS
An osmotically-powered rectal d rug delivery system, was used for the rectal infusion of the m odel drug antipyrine. The system, which is sl ightly larger than a norm al suppository, has a...
https://www.sciencedirect.com/journal/advanced-drug-delivery-reviews/vol/28/issue/2
Rectal drug delivery systems Improvement of rectal peptide absorption by absorption enhancers, protease inhibitors and chemical modification
https://www.slideshare.net/KamleshWadile/rectal-drug-delivery-system
Mar 15, 2016 · Rectal Drug Delivery System 1. 1 RECTAL DRUG DELIVERY SYSTEM Presented By:- KAMLESH A. WADILE (M. 2. 1. Introduction 2. Anatomy & physiology of rectum 3. Absorption from rectum 4. 3. • History: In the 18th century, a French pharmacist, Baume used rectal route for administration... 4. 4 The ...
https://www.slideshare.net/chiranjibi68/rectal-drug-delivery-systems
Jun 22, 2016 · CONCLUSION Rectal administration is truly explored as a potential drug delivery system particularly for drugs that are either too irritating for the gut or undergo extensive first pass metabolism. The rectal drug delivery system offer patients an option that is less invasive and the drug can be administered in unconscious and pediatric patients. Rectal drug delivery with the advantages of enhancement in drug …
https://www.nursingtimes.net/clinical-archive/neurology/rectal-drug-administration-in-adults-how-when-why-22-02-2016/
Rectal absorption results in more of the drug reaching the systemic circulation with less alteration on route. As well as being a more effective route for delivering medication, rectal administration also reduces side-effects of some drugs, such as gastric irritation, nausea and …
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