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https://www.tandfonline.com/doi/abs/10.1080/10837450.2018.1484766
Dec 28, 2017 · Drug delivery via the rectum is a useful alternative route of administration to the oral route for patients who cannot swallow. Traditional rectal dosage forms have been historically used for localized treatments including delivery of laxatives, treatment of hemorrhoids and for delivery …Author: Trusha J. Purohit, Sara M. Hanning, Zimei Wu
https://www.researchgate.net/profile/Raghavendra_Gunda/publication/313161191_RECTAL_DRUG_DELIVERY_SYSTEMS/links/5891a3de458515aeac940f80/RECTAL-DRUG-DELIVERY-SYSTEMS
The history of rectal medication can be traced back to antiquity. These medications were being used in ancient Egypt, India, & Mesopotamia. In the second half of 19 th century a scientific basis...
https://www.slideshare.net/KamleshWadile/rectal-drug-delivery-system
Mar 15, 2016 · Rectal Drug Delivery System 1. 1 RECTAL DRUG DELIVERY SYSTEM Presented By:- KAMLESH A. WADILE (M. 2. 1. Introduction 2. Anatomy & physiology of rectum 3. Absorption from rectum 4. 3. • History: In the 18th century, a French pharmacist, Baume used rectal route for administration... 4. 4 The ...
https://www.pharmatutor.org/articles/discussion-novel-rectal-drug-delivery-systems-recent-review
Rectal drug delivery is an efficient alternate to oral and parenteral route of administration in partial avoidance of first pass metabolism and protein peptide drug delivery. This route allows both local and systemic therapy of drugs.
https://www.nursingtimes.net/clinical-archive/neurology/rectal-drug-administration-in-adults-how-when-why-22-02-2016/
Rectal absorption results in more of the drug reaching the systemic circulation with less alteration on route. As well as being a more effective route for delivering medication, rectal administration also reduces side-effects of some drugs, such as gastric irritation, nausea and vomiting (Tortora and Derrickson, 2008).
http://www.authorstream.com/Presentation/AJ07-983761-rectal-drug-delivery-system/
Apr 27, 2011 · History: The history of rectal medication can be traced back to antiquity. These medications were being used in ancient Egypt, India, & Mesopotamia. In the second half of 19 th century a scientific basis for rectal therapy was established.
https://clinicalgate.com/rectal-and-vaginal-drug-delivery/
Rectal drug delivery. Introduction. Anatomy and physiology of the rectum. Absorption of drugs from the rectum. Rectal dosage forms. Formulation of suppositories. Other rectal preparations. Vaginal drug delivery. Introduction. Anatomy and physiology of the vagina. Absorption of drugs from the vagina. Vaginal dosage forms. Drug-release mechanisms
https://www.pharmaceutical-journal.com/news-and-analysis/features/exploring-the-unconventional-routes-rectal-and-vaginal-dosage-formulations/11105745.fullarticle?firstPass=false
However, drug delivery via the rectal cavity can be challenged by erratic drug absorption due to potential expulsion of the dosage form and low adhesion to the rectal membrane. In addition, drug bioavailability is affected by the site of drug absorption within the rectal cavity. The superior rectal veins go via the liver whereas the inferior rectal veins bypass liver metabolism, thus correct …
http://globalresearchonline.net/journalcontents/v21-1/13.pdf
The rectal routes avoid hepatic first-pass effect. The rectum offers a relatively constant environment for drug delivery provided the drug is presented in a well absorbable form. The rate controlled dosage forms resulting in constant steady-state concentration of drugs in plasma selected therapeutic indications.File Size: 359KB
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