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https://www.ncbi.nlm.nih.gov/pubmed/7950859
Recombinant BCG as an antigen delivery system. Flynn JL(1). Author information: (1)Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261. BCG, an attenuated vaccine strain of Mycobacterium bovis, has been engineered for use as an antigen delivery vehicle.Author: Flynn Jl
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854212/
Sep 07, 2012 · Live recombinant vaccines using bacterial or viral vectors. As a result of advances in the fields of molecular biology and genetic engineering it is now possible to create live recombinant vectors capable of delivering heterologous antigens by the introduction of antigen-encoding genes.Author: I.P. Nascimento, L.C.C. Leite
https://www.scirp.org/journal/PaperInformation.aspx?PaperID=79495
Mice immunized with recombinant BCG expressing DTB showed seroconversion with the detection of specific antibodies against DTB. ... Mycobacterium bovis BCG as a Delivery System for the dtb Gene Antigen ... B. Pereira, G. , Mattos-Guaraldi, A. and G. Armôa, G. (2017) Mycobacterium bovis BCG as a Delivery System for the dtb Gene Antigen from ...Author: Dilzamar V. Nascimento, Odir A. Dellagostin, Denise C. S. Matos, Douglas McIntosh, Raphael Hirata, G...
https://iai.asm.org/content/66/8/3643
Aug 01, 1998 · With the advent of tools for genetic manipulation of mycobacteria, several reports have described the use of recombinant BCG as a potential vaccine vector (2, 19, 31, 32). ... a mycobacterial antigen delivery system for high-level expression of epitopes was developed by using the tetrameric SOD protein of M. tuberculosis as a carrier.Author: Charlotte Hetzel, Riny Janssen, Sarah J. Ely, Nanna M. Kristensen, Karen Bunting, Karen Bunting, Jon...
https://file.scirp.org/pdf/AJMB_2017092914503773.pdf
Mycobacterium bovis Bacillus Calmette-Guerin (BCG) is used as a vaccine for the control of tuberculosis, is currently the most widely used vaccine in the world and has been given to more than three billion people since 1921 [11][10]. For this reason, BCG is among the best live vector candidates for delivery of
https://www.sciencedirect.com/science/article/pii/S0264410X98002552
Furthermore, BCG possesses intrinsic adjuvant properties, especially for the development of cell-mediated immunity, which has recently led to the use of BCG as a heterologous antigen delivery system. Both cellular and humoral immune responses against a number of heterologous antigens have been observed in mice after vaccination with recombinant ...Author: Philip Supply, Philip Sutton, Susie N Coughlan, Katja Bilo, Eric Saman, Alexander J Trees, Marie-Fra...
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