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https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/inhalation/mdi/
About 3M Metered Dose Inhalers. Selection of the right delivery device is a complex decision. Optimizing cost, risk, revenue potential and patient benefit can be difficult. Experience in formulation can reduce the risk of getting a viable product to market, and device development experience can help differentiate your product to maximise revenue...
https://www.3m.com/3M/en_US/drug-delivery-systems-us/technologies/inhalation/intelligentcontrol/
When you know that up to 94% of inhaler users make mistakes using their devices 1, you have to think differently. When up to 60% 2 of patients don’t adhere to their medication, you have to ask why. 3M, with its long history of expertise in inhalation, saw the need for a simple, intuitive,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969498/
Dec 20, 2013 · Upon actuation, the metering valve is designed to deliver the first metered dose from the first formulation (outer reservoir) and the second metered dose from the second formulation, which is housed in the inner reservoir. Typical MDI valves are designed to deliver between 25 and 100 µL of formulation per actuation.Author: Stephen W. Stein, Poonam Sheth, P. David Hodson, Paul B. Myrdal
https://link.springer.com/article/10.1208/s12249-013-0062-y
Dec 20, 2013 · Pressurized metered dose inhalers (MDIs) were first introduced in the 1950s and they are currently widely prescribed as portable systems to treat pulmonary MDIs consist of a formulation containing dissolved or suspended drug and hardware needed to contain the formulation and enable efficient and consistent dose delivery to the patient.Author: Stephen W. Stein, Poonam Sheth, P. David Hodson, Paul B. Myrdal
https://patents.google.com/patent/US7748378B2/en
At this stage, the metered dose of formulation is isolated and ready for discharge from the metering chamber 34 and delivery to the patient. The dimensions of the valve body 22, valve stem 26 and other valve components determine the filled-volume of the metering chamber 34 in …Author: David J. Greenleaf, Peter D. Hodson, Graham Purkins, Gary D. Mahon, Heinz Guenter Klein
http://www.rcjournal.com/contents/09.05/09.05.1177.pdf
The pressurized metered-dose inhaler (pMDI, Fig. 1) quickly became the most important device for delivering inhaled drugs, and today approximately 500 million are produced annually.2 Initially, they were given the acronym “MDI,” but the term “pMDI” is preferable, in order to distinguish them from dry powder inhalers (DPIs) and
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