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https://www.sciencedirect.com/science/article/pii/S0065266005530013
Gene therapy has been deemed the medicine of the future due to its potential to treat many types of diseases. However, many obstacles remain before ge…Author: Christine C. Conwell, Leaf Huang
https://www.genetherapynet.com/non-viral-vectors.html
Non-viral methods present certain advantages over viral methods, with simple large scale production and low host immunogenicity being just two. Previously, low levels of transfection and expression of the gene held non-viral methods at a disadvantage; however, recent advances in vector technolog...
https://link.springer.com/content/pdf/10.1186%2Fs40824-019-0156-z.pdf
On the other hand, non-viral gene delivery system had firstly reported on showing cellular phenotype change via DNA exposures in the body [10, 11]. In this article, the recent advances in the development of gene delivery systems have reviewed, including the progress of viral gene delivery systems and non-viral gene delivery systems.
https://en.wikipedia.org/wiki/Vectors_in_gene_therapy
Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
https://www.sciencedirect.com/science/article/pii/S1879625718300178
Recent successes in developing other avian herpesvirus vaccine strains such as SB-1 of MDV-2 [71 •] and CVI988 (Rispens) of MDV-1 that are known to work together as vaccines against MD, show promise in expanding the recombinant vector portfolio of avian viral vectors.
https://pdfs.semanticscholar.org/0290/f18abb705f2b84c4c298f66da96bb7063d7b.pdf
Keywords: gene delivery; nanomaterials; non-viral vectors; siRNA 1. Introduction Nanotechnology has seen many advances in recent years, both in terms of the development of novel materials, often with tunable properties [1,2] and applications in a growing number of areas. An area of particular interest, and the topic of this review, is gene therapy.
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1402-1
Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery. The ideal treatment for such tissue loss is autografting, but donor sites are often limited. Tissue engineering (TE) is an inspiring alternative for tissue repair and regeneration (TRR). One of the current state-of-the-art methods for TRR is gene therapy. Non-viral gene delivery systems (nVGDS) have ...
https://www.elsevier.com/books/nonviral-vectors-for-gene-therapy-part-1/huang/978-0-12-017653-3
The field of non-viral vector research has rapidly progressed since the publication of the first edition. This new edition is expanded to two separate volumes that contain in-depth discussions of different non-viral approaches, including cationic liposomes and polymers, naked DNA and various physical methods of delivery, as well as a comprehensive coverage of the molecular biological designs ...
https://www.semanticscholar.org/paper/Barriers-and-recent-advances-in-non-viral-vectors-Qaisar-Habib/ea7498c1229c84fb69f63d46a01ea69a81b70a20
On the other hand, non-viral vectors have less toxicity and immunogenic response and are easier to prepare. For a successful gene therapy, the cargo must be delivered to the target site. However, various barriers are faced by non-viral vectors, which make the gene delivery to the target site difficult.
https://onlinelibrary.wiley.com/doi/abs/10.1002/jgm.773
May 27, 2005 · Successful clinical application of synthetic polycations for gene delivery will depend primarily on three factors, namely (1) an enhancement of the transfection efficiency, (2) a reduction in toxicity and (3) an ability of the vectors to overcome numerous …
https://www.researchgate.net/publication/272962037_Advances_in_Gene_Delivery_Systems
Advances in Gene Delivery Systems. ... their use as non-viral vectors for gene delivery can be obtained by including cationic lipids, which provide a positive surface potential that favors binding ...
https://www.polyplus-transfection.com/blog/non-viral-vector-mediated-gene-delivery/
Taking into account the substantial technical progress in safety for viral delivery and efficiency for non-viral delivery, as well as methods used in ongoing gene therapy pre-clinical and clinical trials, there is an emerging tendency for a dedicated scope of use for each method. Viral vector for treatment of monogenic diseases
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jgm.3092
great potential of non‐viral vectors for gene delivery and immunotherapy. Advances in nanotechnology, material sciences and nucleic acid chemistry have resulted in the emergence of non‐viral gene delivery systems with the potential to overcome the limitations of viral vectors and thus comprise a promising gene delivery strategy in the clinic.
https://pubs.acs.org/doi/10.1021/cr800409e
Dec 03, 2008 · Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems. ... for Non-Viral Gene Delivery: High Transfection Efficiency and Low Toxicity Achieved by Increasing Molecular Weight. ... Engineered Glycated Amino Dendritic Polymers as Specific Nonviral Gene Delivery Vectors Targeting the Receptor for Advanced ...
https://www.mdpi.com/2079-9721/6/2/42/pdf
Abstract: Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine. Viral vectors have been employed
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