Rapidly Dissolving Fibroin Microneedles For Transdermal Drug Delivery

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Rapidly dissolving fibroin microneedles for transdermal ...

    https://www.sciencedirect.com/science/article/pii/S0928493111001792
    These rapidly dissolving fibroin MNs provide more benefit than conventional syringes for painless transdermal drug delivery. Highlights This paper presents rapidly dissolving fibroin microneedles (MNs) for the first time. The fibroin MNs can dissolve within minutes under the skin to release the drug molecules. Dissolved fibroin generates non-inflammatory amino-acids usable in cell metabolism.Author: Xueqiu You, Jong Hyeon Chang, Byeong Kwon Ju, James Jungho Pak

Rapidly dissolving fibroin microneedles for transdermal ...

    https://koreauniv.pure.elsevier.com/en/publications/rapidly-dissolving-fibroin-microneedles-for-transdermal-drug-deli
    Dec 01, 2011 · This paper presents rapidly dissolving fibroin microneedles (MNs) for the first time. A reverse PDMS MNs mold was first created and drug-contained fibroin solution was poured into this reverse PDMS MNs mold. Fibroin MNs were successfully fabricated after fan drying and detaching the solidified drug-contained fibroin structure from the PDMS mold.Author: Xueqiu You, Jong Hyeon Chang, Byeong Kwon Ju, James Jungho Pak

Rapidly dissolving fibroin microneedles for transdermal ...

    https://www.researchgate.net/publication/251619657_Rapidly_dissolving_fibroin_microneedles_for_transdermal_drug_delivery
    The fibroin MNs containing methylene blue as a drug were fabricated and their surface morphology, internal structure, mechanical property, and the dissolving characteristics were analyzed. These...

Rapidly separating microneedles for transdermal drug delivery

    https://www.sciencedirect.com/science/article/pii/S1742706116302732
    Sep 01, 2016 · Polymer microneedles offer an attractive, painless and minimally invasive approach for transdermal drug delivery. However, dissolving microneedles require many minutes to be dissolved in the skin and typically have difficulty being fully inserted into the skin due to the skin deformation, which may lead to the low drug delivery efficiency.Author: Dan Dan Zhu, Qi Lei Wang, Xu Bo Liu, Xin Dong Guo

Microneedles: a potential strategy in transdermal delivery ...

    https://pubs.rsc.org/en/Content/ArticleLanding/2020/RA/D0RA00735H
    With the limitation of present drug delivery, the demand for new delivery methods for psoriasis is in the spotlight. Thus, this review paper aims to provide a comprehensive statement about the microneedles, the progress of the microneedle application in the management of psoriasis and the clinical challenges.

Dissolving microneedles for transdermal drug delivery ...

    https://www.sciencedirect.com/science/article/pii/S0753332217324149
    1. Transdermal drug delivery with different microneedles. Microneedles are first applied to the skin (A) and then used for drug delivery (B). The skin is pretreated with solid microneedles and then the drug diffuses through the pores in the skin from a topical drug delivery system (solid MN).Author: Kevin B. Ita

Dissolving Microneedles for Transdermal Drug Delivery

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293299/
    One approach involves pretreatment of skin with microneedles, followed by application of a transdermal patch for extended drug delivery through the permeabilized skin [ 6 ]. Another approach involves coating or encapsulating drug onto or within microneedles. Upon dissolution of the coating or the needle itself,...Author: Jeong Woo Lee, Jung-Hwan Park, Mark R. Prausnitz

Dissolving microneedles for transdermal drug delivery ...

    https://www.sciencedirect.com/science/article/pii/S0142961207010605
    This approach has demonstrated increased transdermal delivery of small-molecule drugs, proteins, DNA, and vaccines , . One approach involves pretreatment of skin with microneedles, followed by application of a transdermal patch for extended drug delivery through the permeabilized skin . Another approach involves coating or encapsulating drug onto or within microneedles.Author: Jeong Woo Lee, Jung-Hwan Park, Mark R. Prausnitz

Rapidly dissolving polymeric microneedles for minimally ...

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097091/
    Oct 05, 2016 · PVP is a homopolymer formed by the monomer N-vinyl-2-pyrrolidone. It is an FDA-approved biocompatible polymer and has been widely used as a blood plasma expander and in pharmaceutical industry for several purposes including as a tablet binder and in fabricating dissolving MNs for transdermal drug delivery [25–27].Author: Raghu Raj Singh Thakur, Ismaiel A. Tekko, Ismaiel A. Tekko, Farhan Al-Shammari, Ahlam A. Ali, Helen ...

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