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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727458/
In these experiments, we have shown that local delivery of rapamycin with α v β 3-targeted perfluorocarbon nanoparticles into the balloon injured vascular wall inhibits stenosis with-out delaying endothelial healing. These findings illustrate the potential benefit of targeted nanoparticulate agents to deliver and to achieve the antirestenotic benefits of rapamycin in lesions that are not amenable to …Author: Tillmann Cyrus, Huiying Zhang, John S. Allen, Todd A. Williams, Grace Hu, Shelton D. Caruthers, Samu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316897/
The results may provide a foundation for the further development of a liposomal delivery system for rapamycin and the establishment of a new active treatment method targeted towards the cellular components of atherosclerotic plaques. The ethanol injection method was used to prepare rapamycin-containing liposomes.Author: Zhi‑Lin Miao, Ying‑Jie Deng, Hong‑Yang Du, Xu‑Bin Suo, Xiao‑Yu Wang, Xiao Wang, Li Wang, Li‑Jie Cui,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1767071/
Rapamycin (sirolimus) has been approved by the US Food and Drug Administration for the prophylaxis of renal transplant rejection. It is a naturally occurring macrocyclic lactone which is highly effective in preventing the onset and severity of disease in several animal models of autoimmune disease, such as insulin dependent diabetes mellitus, systemic lupus erythematosus, and arthritis.Author: P W Serruys, E Regar, A J Carter
https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/1749-8090-6-69
May 12, 2011 · Therefore, this NPs-mediated drug delivery system works as an excellent ex vivo delivery of rapamycin for the excised vein to prevent vein graft failure. Rapamycin is a macrocyclic, lipophilic lactone with immunosuppressive antibiotic activity derived from …Author: Junjie Zou, Xiwei Zhang, Hongyu Yang, Yi Zhu, Hao Ma, Shui Wang
https://www.sciencedirect.com/science/article/pii/S0927776515001113
Apr 01, 2015 · A rapamycin nanomaterial drug delivery system (Fe 3 O 4 /CMCS-Rapa NPs) was designed. The Fe 3 O 4 /CMCS-Rapa NPs were characterized by FT-IR, TEM, VSM and drug release. The Fe 3 O 4 /CMCS-Rapa NPs could enhance cellular uptake of Rapa to tumor cells. The Fe 3 O 4 /CMCS-Rapa NPs could improve the curative effect of drug to tumor cells.Author: Guiyin Li, Guiyin Li, Liangli Cao, Zhide Zhou, Zhencheng Chen, Yong Huang, Yong Huang, Yongxiang Zha...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444623/
Nov 26, 2014 · In Vivo Posterior Ocular Tissue Rapamycin Distribution Studies. Delivery of drug to the back-of-the-eye is a major challenge. Diseases affecting the posterior segment ocular tissues, retina-choroid, require long-term drug delivery.Author: Kishore Cholkar, Sriram Gunda, Ravinder Earla, Dhananjay Pal, Ashim K. Mitra
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