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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995415/
May 05, 2010 · To improve the evaluation of siRNA delivery in vivo, we tailored an approach that quantifies the small RNAs residing in the RISC from the tissues of rodents and monkey. Application of our approach to preclinical animal studies yielded quantitative insights into the in vivo efficiency of siRNA delivery and the mechanism of RNA silencing.Author: Yi Pei, Paula J. Hancock, Hangchun Zhang, René Bartz, Craig Cherrin, Nathalie Innocent, Colin J. Pom...
https://www.researchgate.net/publication/47403681_Quantitative_evaluation_of_siRNA_delivery_in_vivo
To improve the evaluation of siRNA delivery in vivo, we tailored an approach that quantifies the small RNAs residin g in the RISC from the tissues of rodents and monkey.
https://www.researchgate.net/profile/Laura_Sepp-Lorenzino/publication/47403681_Quantitative_evaluation_of_siRNA_delivery_in_vivo/links/02e7e52209ef329b80000000.pdf
between intact siRNA and the free labels released from siRNA by metabolism (Morin et al. 2009). To improve the evaluation of siRNA delivery in vivo, we tailored an approach that quantifiesthesmall ...
https://www.academia.edu/22169872/Quantitative_evaluation_of_siRNA_delivery_in_vivo
Effective small interfering RNA (siRNA)-mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential delivery step is currently inferred from the efficacy
https://www.sciencedirect.com/science/article/pii/S0927775718305880
Oct 20, 2018 · Hence, the evaluation of this carrier system for siRNA delivery is also essential for studies in gene therapy. The electrostatic interaction between siRNA and CLs determines the physico-chemical properties of lipoplexes (siRNA/CL), and is directly related to in vitro and in vivo applications.Author: Ismail Eş, Meryem Tyrrasch Ok, Ximena E. Puentes-Martinez, Marcelo Augusto Szymanski de Toledo, Mari...
https://core.ac.uk/display/8493926
Effective small interfering RNA (siRNA)–mediated therapeutics require the siRNA to be delivered into the cellular RNA-induced silencing complex (RISC). Quantitative information of this essential delivery step is currently inferred from the efficacy of gene silencing and siRNA uptake in the tissue.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778081/
MPGα -MEDIATED DELIVERY OF siRNA AND STERIC BLOCK OLIGONUCLEOTIDES – AN EXAMPLE OF A QUANTITATIVE EVALUATION. Considering the multitude of available CPPs, nucleic acid cargos and cellular as well as animal model systems, a comparison of …Author: S.D Laufer, T Restle
https://www.sciencedirect.com/science/article/pii/S1549963420300332
Trimethyl chitosan-hyaluronic acid nano-polyplexes for intravitreal VEGFR-2 siRNA delivery: Formulation and in vivo efficacy evaluation. ... The transfection of nano-polyplexes was demonstrated in two quantitative and qualitative manners by flow cytometry and confocal microscopy. Furthermore, the ocular tissue distribution of the prepared nano ...Author: Farkhondeh Chaharband, Narsis Daftarian, Mozhgan Rezaei Kanavi, Reyhaneh Varshochian, Maliheh Hajira...
https://covaris.com/category/publications/page/35/
Quantitative evaluation of siRNA delivery in vivo September 21, 2015 / in Publications / by Jeff Rauseo Here we report an approach to directly quantify siRNA in the RISC in rodents and monkey.
https://www.nature.com/articles/nbt.2612
Jun 23, 2013 · Akita, H. et al. Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: programmed endosomal escape and dissociation. ... Pei, Y. …Author: Jerome Gilleron, William Querbes, Anja Zeigerer, Anna Borodovsky, Giovanni Marsico, Undine Schubert,...
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