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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925008/
Pulmonary Delivery as a Route for Insulin Administration. Since the discovery of insulin over 80 years ago, investigators have sought to develop a pulmonary route of insulin delivery. The pulmonary route of administration offers several advantages. First, the lung has a large surface area for drug absorption, ranging from 100 to 140 m 2.Author: Priscilla A. Hollander
https://www.medscape.org/viewarticle/458389
Oct 26, 2019 · Pulmonary Complications in Diabetes. At a symposium on pulmonary insulin delivery, Connie C.W. Hsia, MD, University of Texas Southwestern Medical Center, Dallas, discussed the pulmonary complications of diabetes. Dr. Hsia pointed out that the disease is associated with increased risk of pneumonia and aspiration, that autonomic neuropathy is associated with disordered breathing …
https://www.sciencedirect.com/science/article/pii/S0168365906001155
However, pulmonary delivery of peptides and proteins is complicated by the complexity of the anatomic structure of the human respiratory system and the effect of disposition exerted by the respiration process. In this study, novel nebulizer-compatible liposomal carrier for aerosol pulmonary drug delivery of insulin was developed and characterized.Author: Yi-You Huang, Ching-Hua Wang
https://drug-dev.com/pulmonary-delivery-pulmonary-delivery-of-insulin-to-treat-diabetes-a-debacle/
T.R. Shantha, MD, PhD, FACA, says the market for new anti-diabetic therapeutic agents and their painless delivery is enormous and is sure drug companies and research scientists are in a race to develop a safer method other than the pulmonary and oral routes to deliver insulin.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276033/
In a study by Garcia-Contreras et al. reported systemic delivery of insulin administered by the pulmonary route. The insulin formulations were administered by intratracheal instillation, spray instillation, and subcutaneous route.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/pulmonary-drug-delivery
Pulmonary drug delivery is getting more and more magnitude. This is on account of the specific physiological environment of the lung as an absorption and treatment organ. The development of inhalable insulin can be perceived as a milestone in pulmonary drug delivery.
https://www.researchgate.net/publication/232089096_Pulmonary_delivery_of_insulin
In this review we discuss the possible alternative routes for insulin delivery (ocular, nasal, pulmonary and oral) and advantages and disadvantages of each. ... Development of a product for ...
https://www.pharmatutor.org/articles/pulmonary-drug-delivery-a-review
In the 1920 s adrenaline was introduced as a nebulizer solution, in 1925 nebulizer porcine insulin was used in experimental studies in diabetes, and in 1945 pulmonary delivery of the recently discovered penicillin was investigated. steroids had been introduced in the mid 1950s for the treatment of asthma and nebulizers were enjoying widespread use.
https://www.ondrugdelivery.com/pulmonary-delivery-antimicrobial-peptides/
Insulin is formulated with fumaryl diketopeperazine as the carrier, which self-assembles through hydrogen bonding in mildly acidic environment to form microspheres (Technosphere ®). When addressing tuberculosis via pulmonary delivery, the specific target is the macrophages that carry the MTB inside.
https://www.tandfonline.com/doi/abs/10.1185/030079906X132695
Sep 29, 2006 · The most promising non-invasive route of insulin delivery is via the lung, and there are several novel inhaled insulin formulations and innovative insulin inhalers in development. The most advanced of these, Exubera (insulin human [rDNA origin] Inhalation Powder) was approved for use in adult patients with type 1 or type 2 diabetes in the ...Author: John S. Patton
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