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https://www.sciencedirect.com/science/article/pii/S0168365906001155
Pulmonary delivery of insulin not only provides a non-invasive method but also provides sustained release. Coadministering of insulin with empty liposome also showed the enhancement of insulin adsorption. Pulmonary delivery of liposomal insulin may provide valuable solutions to the currently unmet medical needs. Download : Download full-size imageAuthor: Yi-You Huang, Ching-Hua Wang
https://link.springer.com/article/10.1023%2FA%3A1018934810512
Feb 01, 1993 · The effects of oligomerization and liposomal entrapment on pulmonary insulin absorption were investigated in rats using an intratracheal instillation method. The results indicated that both dimeric and hexameric insulins can be rapidly absorbed into the systemic circulation, producing a significant hypoglycemic response. Intratracheal instillation of insulin in two different oligomerized ...Author: Fang-yu Liu, Zezhi Shao, Dane O. Kildsig, Ashim K. Mitra
https://www.researchgate.net/publication/7051607_Pulmonary_delivery_of_insulin_by_liposomal_carriers
Pulmonary delivery of insulin liposome resulted targeted and homogenous distribution of insulin in the lung alveoli and enhanced lung retention-time, thus resulting in interestingly enhanced ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1925008/
Pulmonary Delivery as a Route for Insulin Administration. Since the discovery of insulin over 80 years ago, investigators have sought to develop a pulmonary route of insulin delivery. The pulmonary route of administration offers several advantages. First, the lung has a large surface area for drug absorption, ranging from 100 to 140 m 2.Author: Priscilla A. Hollander
https://www.sciencedirect.com/science/article/pii/S0168365909001904
The effect of phospholipids on pulmonary insulin delivery was examined in rats . The pulmonary insulin delivery was detected by the change in plasma glucose levels. Plasma glucose levels after pulmonary administration of insulin solution or liposomes containing insulin are shown in Fig. 1A. In the case of insulin solution without enhancers, the ...Author: Sumio Chono, Rie Fukuchi, Toshinobu Seki, Kazuhiro Morimoto
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC188155/
The pulmonary residence time of free and liposome-encapsulated tobramycin was studied with uninfected rats and rats infected with Pseudomonas aeruginosa. Chronic infection in lungs was established by intratracheal administration of 10(8) CFU of P. aeruginosa PA 508 prepared in agar beads.Author: A Omri, C Beaulac, M Bouhajib, S Montplaisir, M Sharkawi, J Lagacé
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