We have collected information about Protein Intracellular Delivery for you. Follow the links to find out details on Protein Intracellular Delivery.
https://www.ncbi.nlm.nih.gov/pubmed/28338410
Intracellular delivery of proteins is potentially a game-changing approach for therapeutics. However, for most applications, the protein needs to access the cytosol to be effective. A wide variety of strategies have been developed for protein delivery, however access of delivered protein to the cytosol without acute cytotoxicity remains a critical issue.Author: Moumita Ray, Yi-Wei Lee, Federica Scaletti, Ruijin Yu, Ruijin Yu, Vincent M Rotello
https://www.cell.com/cell/fulltext/S0092-8674(15)00315-3
Apr 23, 2015 · Protein manipulation is usually achieved indirectly, at the DNA or RNA level, either by “knockdown” or mutation of the encoding gene or by ectopic overexpression of wild-type or mutant genes. Transient, non-integrative modulation of cell function by direct intracellular delivery of proteins has appealing application,...Author: Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, Wouter R. Karthaus, Hans Clevers, Vikram Prasad,...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4783992/
Feb 22, 2016 · Recombinant proteins that include a CPP tag to promote intracellular delivery show promise as therapeutic agents with encouraging success rates in both animal and human trials. This review highlights recent advances in protein-CPP therapy and discusses optimization strategies and potential detrimental effects.Author: Ana Dinca, Wei Ming Chien, Michael T. Chin
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201711651
Intracellular delivery of native proteins for immediate bioavailability. A) HRP delivery to live HeLa cells followed by measurement of enzymatic activities. Cells were treated with HRP (50 nm, 1.5 h) following each delivery formula, before being washed, fixed and …Author: Linghui Qian, Jiaqi Fu, Peiyan Yuan, Shubo Du, Wei Huang, Lin Li, Shao Q. Yao
http://www.jbc.org/content/276/37/35103.long
Sep 14, 2001 · Cationic lipids have also been used to deliver protein into the intracellular processing pathway leading to antigen presentation, but the discrimination between inside and outside antigen presentation was difficult and the efficiency of functional intracellular protein delivery remains unclear .Author: Olivier Zelphati
https://pubs.rsc.org/en/content/articlelanding/2011/cs/c0cs00227e
Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering active forms of proteins to specific cells and organs. Intracellular protein delivery holds enormous promise for biological and medical applications,Author: Zhen Gu, Anuradha Biswas, Muxun Zhao, Yi Tang
https://onlinelibrary.wiley.com/doi/10.1002/anie.201901699
Mitochondria‐Targeting, Intracellular Delivery of Native Proteins Using Biodegradable Silica Nanoparticles. Dr. Peiyan Yuan. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543 Singapore. School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510275 China.Author: Peiyan Yuan, Peiyan Yuan, Xin Mao, Xiaofeng Wu, Si Si Liew, Lin Li, Shao Q. Yao
https://www.nature.com/articles/ncomms12277
Jul 22, 2016 · Intracellular proteins have been identified for their potential as biopharmaceutical drugs; however, many of the challenges associated with intracellular protein delivery have yet to be solved 1.Author: Nambin Yim, Seung Wook Ryu, Kyungsun Choi, Kwang Ryeol Lee, Seunghee Lee, Hojun Choi, Jeongjin Kim, ...
https://pubs.acs.org/doi/10.1021/jacs.8b12705
A review. The direct delivery of functional proteins into the cell cytosol is a key issue for protein therapy, with many current strategies resulting in endosomal entrapment. Protein delivery to the cytosol is challenging due to the high mol. wt. and the polarity of therapeutic proteins.Author: Shunzhi Wang, Yijing Chen, Shuya Wang, Peng Li, Chad A. Mirkin, Omar K. Farha
Searching for Protein Intracellular Delivery?
You can just click the links above. The data is collected for you.
