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https://www.nature.com/articles/nature05272
Nov 30, 2006 · The type III secretion system (T3SS) is a bacterial organelle that delivers bacterial proteins into eukaryotic cells. First identified in pathogens, genome scanning has …Author: Jorge E. Galán, Hans Wolf-Watz
https://www.researchgate.net/publication/337833869_High_Efficiency_Protein_Delivery_into_Transfection-Recalcitrant_Cell_Types
capable of high ‐ efficiency protein delivery into target cells. Further-more, a short coculture of the ES cells with the protein delivery strain
https://ui.adsabs.harvard.edu/abs/2006Natur.444..567G
Bacteria that have sustained long-standing close associations with eukaryotic hosts have evolved specific adaptations to survive and replicate in this environment. Perhaps one of the most remarkable of those adaptations is the type III secretion system (T3SS)-a bacterial organelle that has specifically evolved to deliver bacterial proteins into eukaryotic cells. Although originally identified ...Author: Jorge E. Galán, Hans Wolf-Watz
https://advances.sciencemag.org/content/5/8/eaax0064.full
Aug 01, 2019 · Development of safe and efficient nanoscale vehicles that can deliver large molecular cargos into human cells could transform future human therapies and personalized medicine. Here, we design a hybrid viral vector composed of a prokaryotic virus (bacteriophage T4) and a eukaryotic virus [adeno-associated virus (AAV)]. The small 25-nm AAV is attached to the large 120 nm × 86 nm T4 …Author: Jingen Zhu, Pan Tao, Marthandan Mahalingam, Jian Sha, Paul Kilgore, Ashok K. Chopra, Venigalla Rao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6748792/
Sep 17, 2019 · Secondly, like T6SS but unlike R-type Pyocins, they are evolved to inject bioactive protein effectors into other cells. We hypothesise that the PVCs are evolved to specifically target eukaryotic cells, unlike T6SS, which have been shown to be able to …Author: Isabella Vlisidou, Alexia Hapeshi, Joseph Rj Healey, Katie Smart, Guowei Yang, Nicholas R Waterfield
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-0854.2006.00446.x
tumefaciens utilizes the T4a pathway to deliver a nucleoprotein complex consisting of oncogenic transfer (T‐DNA) to plant cells, where it will integrate into the eukaryotic chromosome with the guidance of other effector protein substrates .Author: Eric D. Cambronne, Craig R. Roy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388319/
The last step in the T3SS-mediated delivery of effector proteins into eukaryotic cells is their passage through the target host-cell membrane (see below). This process is mediated by the protein translocases (SipB/SipC, IpaB/IpaC, and YopB/YopD in Salmonella, Shigella and Yersinia, respectively) (28; 122).Author: Jorge E. Galán, Maria Lara-Tejero, Thomas C. Marlovits, Samuel Wagner
https://www.thno.org/v09p3280.htm
Protein delivery into cells is a potentially transformative tool for treating “undruggable” targets in diseases associated with protein deficiencies or mutations. The vast majority of these targets are accessed via the cytosol, a challenging prospect for proteins with therapeutic and diagnostic relevance.
https://science.sciencemag.org/content/284/5418/1322.full
May 21, 1999 · Several Gram-negative pathogenic bacteria have evolved a complex protein secretion system termed type III to deliver bacterial effector proteins into host cells that then modulate host cellular functions. These bacterial devices are present in both plant and animal pathogenic bacteria and are evolutionarily related to the flagellar apparatus.Author: Jorge E. Galán, Alan Collmer
http://adsabs.harvard.edu/abs/2006Natur.444..567G
Protein delivery into eukaryotic cells by type III secretion machines: Authors: Galán, Jorge E.; ... Abstract Bacteria that have sustained long-standing close associations with eukaryotic hosts have evolved specific adaptations to survive and replicate in this environment. Perhaps one of the most remarkable of those adaptations is the type III ...
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