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https://www.researchgate.net/publication/7733332_Protein_crystals_for_the_delivery_of_biopharmaceuticals
tion of protein crystals fo r the delivery of biopharmaceuticals. F irst, protein crystallisation needs to be applied to a vast rang e o f therap eutic p rotein s.
https://www.tandfonline.com/doi/abs/10.1517/14712598.4.3.301
Apr 20, 2018 · Protein crystals have shown significant benefits in the delivery of biopharmaceuticals to achieve high concentration, low viscosity formulation and controlled release protein delivery.Author: Sujit K Basu, Chandrika P Govardhan, Chu W Jung, Alexey L Margolin
https://drug-dev.com/protein-crystals-reshaping-traditional-biotherapeutic-formulations/
Basu et al. Protein crystals for the delivery of biopharmaceuticals. Expert Opinion Biological Ther. 2004;4(3):301-317. Don Paul Kovarcik is the Technical Marketing Specialist at Ajinomoto Althea, Inc.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451076/
Protein delivery platforms are important tools in the development of novel protein therapeutics and biotechnologies. We have developed a new class of protein delivery agent based on sub-micrometer-sized Cry3Aa protein crystals that naturally form within the bacterium Bacillus thuringiensis.We demonstrate that fusion of the cry3Aa gene to that of various reporter proteins allows for the facile ...Author: Manoj S. Nair, Marianne M. Lee, Astrid Bonnegarde-Bernard, Julie A. Wallace, Donald H. Dean, Michael...
https://www.pnas.org/content/96/17/9469
Aug 17, 1999 · Protein crystals present highly concentrated and highly ordered structures . The solvent content of typical protein crystals is composed of uniform solvent-filled channels that ranges from 30% to 65% of the total crystal volume . For example, the porosity of CLPC–HSA was determined to be 65% .Author: Nancy St. Clair, Bhami Shenoy, Lawrence D. Jacob, Alexey L. Margolin
https://pubs.acs.org/doi/abs/10.1021/ja973449%2B
Cross-linked protein crystals (CLPCs) constitute a novel type of molecular sieves with high porosity. In order to characterize the fully hydrated CLPC, the method of macromolecular porosimetry was applied. This technique allows one to estimate the apparent pore sizes and pore size distribution in solid and soft hydrated porous sorbents directly from size exclusion chromatography.Author: Lev Z. Vilenchik, James P. Griffith, Nancy St. Clair, Manuel A. Navia, Alexey L. Margolin
https://www.cell.com/trends/biotechnology/pdf/S0167-7799(98)01186-X.pdf
administration for the systemic delivery of peptide and protein pharmaceuticals3,4. Of the noninvasive routes for the delivery of proteins and peptides, the pulmonary route has provided the most encouraging data and has recently generated great interest from the biotechnol-ogy industry. Dry or liquid particles can be prepared
https://www.sciencedirect.com/science/article/pii/S1385894717312202
Silica nanospheres entrapped with ultra-small luminescent crystals for protein delivery. ... M.G. WackerOptimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques. J. Control. Release, 235 (2016), pp. 352-364. Google Scholar.Author: Yangyang Li, Xiaoyi Chen, Heng Liu, Xiaozhou Mou, Zhaohui Ren, Zeeshan Ahmad, Xiang Li, Gaorong Han
https://www.mdpi.com/1999-4923/10/3/131/htm
Numerous drying technologies, including FD, SD, SFD, and SCFD, have been used for dried protein formulations, and they have become an important method for the manufacture, storage, and delivery of protein-based biopharmaceuticals [14,25,26,37].Author: Fakhrossadat Emami, Alireza Vatanara, Eun Ji Park, Dong Hee Na
https://link.springer.com/content/pdf/10.1007%2Fs11095-005-6021-x.pdf
Aug 24, 2005 · Novel Long-Acting Crystal Formulation of Human Growth Hormone. Chandrika Govardhan 1 ... ArticleTitle Protein crystals for the delivery of biopharmaceuticals Expert Opin. Biol. Ther. 4 301–317 ... Jung, C.W. et al. Novel Long-Acting Crystal Formulation of Human Growth Hormone. Pharm Res 22, 1461–1470 ...Author: Chandrika Govardhan, Nazer Khalaf, Chu W. Jung, Ben Simeone, Amy Higbie, Susan Qu, Letha Chemmalil, ...
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